Study Country Sample size (antioxidant/control) Population characteristic (antioxidant/control) Intervention (antioxidant/control) Subgroup on antioxidants Control group Duration of intervention Caballero [1 ] UK 36/78 Age(years):2 ): The Ascophyllum (poly)phenol-rich blend 400 mg/day Water-soluble antioxidants Placebo 8 weeks Collaborators et al. [2 ] Poland 30/30 Age (years): 2 ): Average arginine 43.3 mg/kg/day bodyweight in women and 48.6 mg/kg/day in men Water-soluble antioxidants Placebo 3 months Bazrafshani et al. [3 ] Iran 16/19 Age (years): 2 ): L-selenomethionine (S) 240 μ g/day Water-soluble antioxidants Placebo 12 weeks Valerio et al. [4 ] Iran 27/28 Age (years): 2 ): L-arginine 6 g/d Water-soluble antioxidants Placebo 8 weeks Malone and Hansen [5 ] Brazil 24/22 BMI (kg/m2 ): Roasted baru almonds 20 g/day Mixed Placebo 8 weeks Nikolopoulou and Kadoglou [6 ] Brazil 24/22 BMI (kg/m2 ): Roasted baru almonds 20 g/day Mixed Placebo 8 weeks Milic et al. [7 ] USA 19/19 BMI (kg/m2 ): Dried apple 240 kcal/day Mixed Placebo 8 weeks Fernández-Sánchez et al. [8 ] Iran 25/25 Age (years): 2 ): Zinc gluconate (contained 30 mg/d elemental zinc) Water-soluble antioxidants Placebo 12 weeks Fonseca-Alaniz et al. [9 ] Iran 23/22 Age (years): 2 ): ALA 1200 mg/day plus vitamin E 400 mg/day Fat-soluble antioxidants Placebo 12 weeks Dludla et al. [10 ] Iran 30/30 Age (years): 2 ): Majoun 10 g/day Water-soluble antioxidants Placebo 12 weeks Bjorklund and Chirumbolo [11 ] Iran 35/35 Age (years): 2 ) Caraway seed extract 30 ml/day Water-soluble antioxidants Placebo 12 weeks Ohishi et al. [12 ] Iran 18/22 Age (years): 2 ): Zinc 30 mg/day Water-soluble antioxidants Placebo 15 weeks Szulinska et al. [13 ] Germany 23/23 BMI (kg/m2 ): Epicatechin 25 mg/day Water-soluble antioxidants Placebo 2 weeks Hosseinpour-Arjmand [14 ] China 30/29 Age (years): 2 ): 29 multivitamins and minerals one tablet/day Mixed Placebo 26 weeks Callcott et al. [15 ] Brazil 30/39 Age (years): 2 ): HD+frozen açaí (Euterpe oleracea Mart) 200 g/day Water-soluble antioxidants HD+placebo 60 days Zhao et al. [16 ] Mexico 15/24 Age (years): 2 ): Resveratrol 100 mg/day Fat-soluble antioxidants Placebo 24 weeks Showell et al. [17 ] Brazil 28/28 Age (years): 2 ): Zinc aminochelate 30 mg/day Water-soluble antioxidants Placebo 30 days Emami et al. [18 ] Iran 29/29 Age (years): 2 ): Dried licorice extract 0.5 g/day Water-soluble antioxidants Placebo 8 weeks Ekhlasi et al. [19 ] Netherlands 11/14 Age (years): 2 ): Polyphenols epigallocatechin-gallate 282 mg/d and resveratrol 80 mg/d Water-soluble antioxidants Placebo 12 weeks Shadman et al. [20 ] Poland 28/28 Age (years): 2 ): Green tea extract 1 capsule/day Water-soluble Placebo 8 weeks Showell et al. [21 ] Iran 30/30 Age (years): 2 ): Zinc 30 mg/kg Water-soluble antioxidants Placebo 4 weeks Smits et al. [22 ] Poland 24/35 Age (years): 2 ): DHA and EPA given in 3 capsules/day Fat-soluble antioxidants Placebo 12 weeks Piche et al. [23 ] Brazil 13/14 Age (years): 2 ): Juçara berry (Euterpe edulis Mart.) freeze-dried pulp 5 g/day Mixed Placebo 6 weeks Leisegang et al. [24 ] USA 15/17 Age (years): 2 ): Blueberry powder 45 g/day Mixed Placebo 8 weeks Park et al. [25 ] Poland 44/44 Age (years): 2 ): The average arginine 43.3 mg/kg/day Water-soluble antioxidants Placebo 6 months Dostal et al. [26 ] Poland 15/15 Age (years): 2 ): Melatonin 10 mg/day Fat-soluble antioxidants Placebo 30 days Zhang et al. [27 ] Poland 25/25 Age (years): 2 ): Spirulina 0.5 g/day Water-soluble antioxidants Placebo 12 weeks Farr et al. [28 ] Poland 46/46 Age (years): 2 ): Extract of garlic (2% allicin) 400 mg/d Mixed Placebo 12 weeks Yadav et al. [29 ] Iran 25/25 Age (years): 2 ): Green tea 1 g/day, capsaicin 100 mg/day, and ginger 200 mg/day Water-soluble antioxidant Placebo 8 weeks Balsan et al. [30 ] Australia 28/28 Age (years): 2 ): A fruit and vegetable concentrate supplement Mixed Placebo 8 weeks
