The Combination of Rhodosin and MMF Prolongs Cardiac Allograft Survival by Inhibiting DC Maturation by Promoting Mitochondrial Fusion

Figure 8

Diagram of Rho preventing from acute rejection in heart transplantation. In MHC II-full mismatch cardiac transplantation, we proved that combination of Rho and MMF prolongs cardiac transplantation survival, and Rho can promote the mitochondrial fusion mainly by MFN1 and decrease the level of ROS, then induce tolerogenic DCs which can suppress the Teff population and increases the Treg, so the Rho plays an immune tolerant effect in murine heart transplantation.