Celastrol Protects against Cerebral Ischemia/Reperfusion Injury in Mice by Inhibiting Glycolysis through Targeting HIF-1α/PDK1 Axis

Figure 1

Effects of different doses of celastrol on cerebral I/R injury. (a) Neurological score in each group (). (b) Representative TTC staining of brain sections among different groups at 24 h after reperfusion. (c) Statistical analysis of cerebral infarct volume (). (d) HE staining of the ipsilateral cortex at 24 h after reperfusion. (e) Statistical analysis of dead cells in cortex (magnification: 400×) (). The data are presented as . compared with the sham group; , , and compared with the I/R group; and compared with the I/R + 3 mg/kg Celastrol group.

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