STING Induces Liver Ischemia-Reperfusion Injury by Promoting Calcium-Dependent Caspase 1-GSDMD Processing in Macrophages

Figure 8

Diagram representing the putative mechanism by which STING induces liver IRI by promoting calcium-dependent pyroptosis of macrophages. During liver IRI, STING in liver macrophages increased intracellular calcium to promote caspase 1-GSDMD processing, and then IL-1β and IL-18 were secreted and released, which ultimately aggravated liver injury.