Research Article

Suppression of Selective Voltage-Gated Calcium Channels Alleviates Neuronal Degeneration and Dysfunction through Glutathione S-Transferase-Mediated Oxidative Stress Resistance in a Caenorhabditis elegans Model of Alzheimer’s Disease

Figure 1

Calcium acetate aggravated Aβ-induced neurodegenerative motor impairments, while EGTA inhibited neurodegenerative dysfunction and extended the life span of Aβ worms. (a) Time course of Aβ-induced paralysis in CL4176 worms treated with/out calcium acetate. CL802 was the control strain. (b) CI values of calcium acetate -treated vs. untreated CL2355 worms. CL2122 was the control strain. (c) Body bends capacity of calcium acetate-treated vs. untreated CL2355 worms. CL2122 was the control strain. (d) Time course of lifespan of calcium acetate-treated vs. untreated CL4176 worms. CL802 was the control strain. (e) Time course of Aβ-induced paralysis in CL4176 worms treated with/out EGTA. (f) CI values of EGTA-treated vs. untreated CL2355 worms. (g) Body bends capacity of EGTA-treated vs. untreated CL2355 worms. (h) Time course of lifespan of EGTA-treated vs. untreated CL4176 worms. Error bars indicate SEM. ( vs. control, vs. control).
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