Research Article

Suppression of Selective Voltage-Gated Calcium Channels Alleviates Neuronal Degeneration and Dysfunction through Glutathione S-Transferase-Mediated Oxidative Stress Resistance in a Caenorhabditis elegans Model of Alzheimer’s Disease

Figure 2

Calcium acetate aggravated impairment of GABAergic and motor neurons in the VNC, while EGTA and nimodipine postponed lesion development in Aβ worms. (a) Representative images of D-type GABAergic neurons in the VNCs of EG1285, NUCM0001, calcium acetate-treated NUCM0001, EGTA-treated NUCM0001, and nimodipine-treated NUCM0001 worms (scale bar, 50 μm). Histogram showing the number of lost D-type GABAergic neurons in NUCM0001 worms treated with/out calcium-adjusting agents. Lost neurons are indicated by triangles. (b) Representative images of motor neurons in the VNCs of BL5717, NUCM0002, calcium acetate -treated NUCM0002, EGTA-treated NUCM0002, and nimodipine-treated NUCM0002 worms (scale bar, 50 μm). Histogram of the fluorescence intensity of cell bodies of NUCM0002 worms treated with/out calcium-adjusting agents. Lost neurons are indicated with triangles. Motor neurons are indicated with arrows. Error bars indicate the SEM. ( vs. control, vs. control).
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