Research Article

Suppression of Selective Voltage-Gated Calcium Channels Alleviates Neuronal Degeneration and Dysfunction through Glutathione S-Transferase-Mediated Oxidative Stress Resistance in a Caenorhabditis elegans Model of Alzheimer’s Disease

Figure 6

Nimodipine upregulated the transcript levels of genes encoding antioxidative enzymes (HPGDS and GST). (a) Relative mRNA levels of genes relevant to antioxidative stress in CL2355 worms treated with/out nimodipine. (b) Representative images of gst-4P::GFP expression in CL2166 and CL2166 worms treated with PQ, CL2166, and nimodipine (scale bar, 100 μm). (c) Histogram of gst-4P::GFP relative fluorescence intensity/body area of the worm.