Research Article

Suppression of Selective Voltage-Gated Calcium Channels Alleviates Neuronal Degeneration and Dysfunction through Glutathione S-Transferase-Mediated Oxidative Stress Resistance in a Caenorhabditis elegans Model of Alzheimer’s Disease

Figure 7

Suppression of selective VGCCs enhanced oxidative stress resistance through regulation of HPGDS and GST activities in CL2355 Aβ worms. (a) Activity of clhm-1, unc-68, or ncx-1 in regulating the effect of nimodipine on the CI value. L4440 is an empty vector. (b) Activity of clhm-1, unc-68, or ncx-1 in regulating the effect of nimodipine on body bending capacity. L4440 is an empty vector. (c) Relative mRNA levels of genes relevant to antioxidative stress in CL2355 and CL2355 clhm-1 (RNAi) worms treated with nimodipine (d) Relative mRNA levels of genes relevant to antioxidative stress in CL2355 and CL2355 unc-68 (RNAi) worms treated with nimodipine. (e) Relative mRNA levels of genes relevant to antioxidative stress in CL2355 and CL2355 ncx-1 (RNAi) worms treated with nimodipine. The treatment concentration of nimodipine was 1 mM. Error bars indicate the SEM. ( vs. control, vs. control).
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