Pioglitazone Hydrochloride Extends the Lifespan of Caenorhabditis elegans by Activating DAF-16/FOXO- and SKN-1/NRF2-Related Signaling Pathways

Figure 5

The effect of PGZ on lifespan extension is independent of mitochondrial function. (a, b) Survival analyses of isp-1(qm150) (a) and clk-1(e2519) (b) mutants exposed or not exposed to 0.5 mM PGZ ( value by the log-rank test). The lifespan values of repeat experiments were summarized in Supplementary Table S1. (c) Mechanisms of action of PGZ in C. elegans.

(a)

(b)

(c)