Dapagliflozin Ameliorates the Formation and Progression of Experimental Abdominal Aortic Aneurysms by Reducing Aortic Inflammation in Mice

<div>Influence of dapagliflozin on medial elastin, SMC destruction, and aortic macrophages infiltration on existing AAAs. EVG, SMC <i>α</i>-actin, and CD68 (macrophage) staining were performed on aortic frozen sections, graded, and semiquantified. (a) Representative aortic images for medial elastin EVG staining, SMC immunostaining, and aortic macrophages immunostaining. (b)–(d) Mean and SD of elastin degradation score (b), SMC depletion score (c), and macrophages in aneurysmal aortae. 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240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g></svg> (vehicle) and 8 (dapagliflozin at 5 mg/kg) mice. DAPA: dapagliflozin.</div>

Oxidative Medicine and Cellular Longevity

fig7

Figure 7

Figure 7: Dapagliflozin Ameliorates the Formation and Progression of Experimental Abdominal Aortic Aneurysms by Reducing Aortic Inflammation in Mice 