Osthole Induces Apoptosis and Caspase-3/GSDME-Dependent Pyroptosis via NQO1-Mediated ROS Generation in HeLa Cells

<div>Osthole suppresses HeLa xenograft tumor growth, induces apoptosis and pyroptosis <i>in vivo</i>. (a) Tumor volume was recorded every 2 days. (b) The average weight of tumor in control and osthole-treated groups. (c) Representative images of unstripped tumor after being treated for 21 days. (d) The body weight of nude mice treated with or without osthole for 21 days. (e) The expression proteins were determined by western blotting. (f) The intensity of bands was quantified by Image J, and <i>β</i>-actin was used as a control. 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Oxidative Medicine and Cellular Longevity

fig7

Figure 7

Figure 7: Osthole Induces Apoptosis and Caspase-3/GSDME-Dependent Pyroptosis via NQO1-Mediated ROS Generation in HeLa Cells 