Low-Temperature Plasma-Activated Medium Inhibited Proliferation and Progression of Lung Cancer by Targeting the PI3K/Akt and MAPK Pathways

<div>PAM inhibition effect in 3D lung cancer spheroids. Morphological change of 3D A549 spheroids (a) and 3D SK-MES-1 spheroids (b) after PAM treatment. Live/dead assay of 3D A549 spheroids (c) and 3D SK-MES-1 spheroids (d) with PAM treatment for 48 h; the qualification of dead cells by ImageJ software were presented in the right panel. Stemness-related mRNA expression of (e) 3D A549 spheroids and (f) 3D SK-MES-1 spheroids. Nontreated spheroids were used as control. 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Oxidative Medicine and Cellular Longevity

fig4

Figure 4

Figure 4: Low-Temperature Plasma-Activated Medium Inhibited Proliferation and Progression of Lung Cancer by Targeting the PI3K/Akt and MAPK Pathways 