Research Article

A Mixture of Ginkgo biloba L. Leaf and Hericium erinaceus (Bull.) Pers. Fruit Extract Attenuates Scopolamine-Induced Memory Impairments in Mice

Figure 1

Effect of the mixture (GH) of Ginkgo biloba L. leaf (GL) and Hericium erinaceus (Bull.) Pers. (HE) fruit extracts on scopolamine- (Sco-) induced mouse model. (a) In vivo experiments were performed as shown in the schematic diagram. Each group was orally administered with GH (240 mg/kg), GL (40 mg/kg), HE (200 mg/kg), PC (1 mg/kg donepezil), or water. Before behavior tests (30 min), Sco was intraperitoneally injected for constructing the memory deficit model. (b, c) The Y-maze test was performed 30 min later. Spontaneous alternation percentage (b) and total numbers of arm entries (c) were recorded. (d) NORT test was performed 30 min later. The exploration times of the familiar and novel objects were recorded. Each group was orally administered with GH (240 mg/kg), GL (40 mg/kg), HE (200 mg/kg), PC (1 mg/kg donepezil), or water. Before behavior tests (30 min), Sco was intraperitoneally injected for constructing the memory deficit model. All behavior tests were analyzed by using video tracking software. Each behavior represents the (–5). # and ## vs. control group. vs. Sco-treated group.
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