Dietary High-Fat Promotes Cognitive Impairment by Suppressing Mitophagy

Figure 8

Potential mechanism of fat-induced cognition impairment. The HFD damages the mitochondria, inhibits mitophagy, and causes Tau protein phosphorylation and synaptic damage, eventually leading to cognitive dysfunction. Abbreviations: HFD: high-fat diet; BDNF: brain-derived neurotrophic factor; PSD95: postsynaptic density protein 95; SYN: synaptophysin; ATP: adenosine triphosphate; ROS: reactive oxygen species; IR: insulin resistance; NFT: neurofibrillary tangles.