A Novel Scientometrics Research on the Interaction between Oxidative Stress and Hematopoietic Stem Cell Transplantation Complications: From Graft-versus-Host Disease to Sepsis

Table 2

The multidimensional presentation and intensive reading of recently published literatures.

Author	Journal/IF/year	Study object	Treatment	Result	Conclusion
Patterson et al.	Stem Cell Rev Rep; IF:6.692/2021	Patients with multiple myeloma	Patients received meloxicam with filgrastim before apheresis.	The number of CD34+ cells collected decreased significantly, the expression of CXCR4 on CD34+ cells decreased, and the proportion of CD4+/CD8+ T cells increased. RNA sequencing showed downregulation of oxidative phosphorylation related genes.	Mitigate hematopoietic stem and progenitor cells oxidative stress. Lessen stem cell exhaustion and enhance graft quality.
Rodionov et al.	Bone Marrow Transplant; IF:5.174/2022	G-CSF mobilized human peripheral blood cells and nonobese diabetic-severe combined immune deficiency (NOD-SCID) IL2Rγnull (NSG) mice.	A treatment of MPBCs with Fas ligand (FasL, CD95L).	Selectively induce apoptosis of CD3+ T cells, B cells, and antigen presenting cells, but CD34+ hematopoietic stem cells and progenitors. Reduce IFN-γ secreted by cells.	Increase the possibility of graft survival and function, reduce GVHD, and reduce the proinflammatory capacity of macrophages.
Wang et al.	Int Immunopharmacol; IF:5.714/2020	BALB/c (H-2d) mice induced GVHD.	Treated with the combination of BBR and CsA.	Reduce weight loss and GVHD index scores. Reduce intestinal and liver damage, inflammation, and oxidative stress. Suppress NF-κB signaling in liver and intestine. Reduce the number of Th1 cells.	Reduce oxidative stress and alleviate inflammatory response induced by acute GVHD. Improve the survival rate of GVHD mice.
Rezende et al.	J Immunol Res; IF:4.493/2019	C57BL/6 and B6D2F1 mice induced GVHD.	Intraperitoneally inject apocynin during the experiments.	The treated mice reduced mortality and disease progression, reduced oxidative stress, reduced liver and intestinal damage, and inhibited inflammation.	Regulate the inflammatory response related to GVHD without impairing the engraftment which is associated with controlling oxidative stress.