Oxidative Medicine and Cellular Longevity

Cellular and Molecular Mechanisms of Oxidative Stress in Stroke


Publishing date
01 Apr 2021
Status
Closed
Submission deadline
27 Nov 2020

Lead Editor

1Fudan University, Shanghai, China

2Mie University, Tsu, Japan

3Polish Academy of Sciences, Warsaw, Poland

4Loma Linda University, Loma Linda, USA

This issue is now closed for submissions.
More articles will be published in the near future.

Cellular and Molecular Mechanisms of Oxidative Stress in Stroke

This issue is now closed for submissions.
More articles will be published in the near future.

Description

According to a report from the World Health Organization (WHO), stroke now is considered as the second leading cause of death and accounts for about 9% of deaths worldwide each year. It usually causes neurological deficits to patients, threatens people’s health, and increases the burden of medical expenses. Thus, new treatments are urgently needed to improve prognosis and minimize complications.

Studies have found that reactive oxygen species (ROS) have been implicated in brain injury induced by ischemic stroke. There is a rapid increase in the production of ROS immediately after acute ischemic stroke. This overwhelming antioxidant defence would cause further tissue damage. These ROS can damage cellular macromolecules leading to autophagy, apoptosis, and necrosis. However, current measures to protect the brain against severe stroke damage are insufficient. Thus, it is critical to investigate antioxidant strategies that lead to the diminution of oxidative injury.

The aim of this Special Issue is to collate any manuscripts related to the mechanisms involved in ROS generation, the role of oxidative stress in the pathogenesis of ischemic stroke, and the novel therapeutic strategies to be tested to reduce cerebral damage.

Potential topics include but are not limited to the following:

  • Antioxidant strategies that alleviate oxidative injury after stroke
  • Brain haemorrhage and oxidative stress
  • Cell death mechanisms and oxidative stress
  • Endoplasmic reticulum stress and oxidative stress in stroke
  • Genetics of oxidative stress in stroke
  • Global and neonatal brain injury and oxidative stress
  • Neuroinflammation and oxidative stress
  • Novel therapeutic strategies to reduce cerebral damage in stroke
  • Oxidative stress and arteriosclerosis
  • Oxidative stress and lifestyle disease in stroke
  • Oxidative stress and proteasome dysfunction in stroke
  • Oxidative stress and vascular dementia
  • Oxidative stress biomarkers in stroke
  • Oxidative stress mechanisms in stroke
  • Stem cells and oxidative stress in stroke
  • Surgical treatment and oxidative stress

Articles

  • Special Issue
  • - Volume 2021
  • - Article ID 5913424
  • - Research Article

IL-20R Activation via rIL-19 Enhances Hematoma Resolution through the IL-20R1/ERK/Nrf2 Pathway in an Experimental GMH Rat Pup Model

Shengpeng Liu | Jerry J. Flores | ... | John H. Zhang
  • Special Issue
  • - Volume 2021
  • - Article ID 5653948
  • - Research Article

Preliminary Study on the Application of Ultrahigh Field Magnetic Resonance in Moyamoya Disease

Jiabin Su | Wei Ni | ... | Ying Mao
  • Special Issue
  • - Volume 2020
  • - Article ID 8823283
  • - Research Article

Nomogram to Predict Poor Outcome after Mechanical Thrombectomy at Older Age and Histological Analysis of Thrombus Composition

Longyan Meng | Haichao Wang | ... | Yanxin Zhao
  • Special Issue
  • - Volume 2020
  • - Article ID 8880244
  • - Research Article

The Poststroke Peripheral Immune Response Is Differentially Regulated by Leukemia Inhibitory Factor in Aged Male and Female Rodents

Stephanie M. Davis | Lisa A. Collier | ... | Keith R. Pennypacker
  • Special Issue
  • - Volume 2020
  • - Article ID 8877116
  • - Review Article

The Role of Oxidative Stress in Early Brain Injury after Subarachnoid Hemorrhage

M. Jelinek | M. Jurajda | K. Duris
  • Special Issue
  • - Volume 2020
  • - Article ID 8864100
  • - Research Article

Activation of the Melanocortin-1 Receptor by NDP-MSH Attenuates Oxidative Stress and Neuronal Apoptosis through PI3K/Akt/Nrf2 Pathway after Intracerebral Hemorrhage in Mice

Siming Fu | Xu Luo | ... | Zongyi Xie
  • Special Issue
  • - Volume 2020
  • - Article ID 8884320
  • - Research Article

Valproate Sodium Protects Blood Brain Barrier Integrity in Intracerebral Hemorrhage Mice

Wei Zhao | Lianhua Zhao | ... | Yijun Song
  • Special Issue
  • - Volume 2020
  • - Article ID 7308386
  • - Research Article

Notoginseng Leaf Triterpenes Ameliorates OGD/R-Induced Neuronal Injury via SIRT1/2/3-Foxo3a-MnSOD/PGC-1α Signaling Pathways Mediated by the NAMPT-NAD Pathway

Weijie Xie | Ting Zhu | ... | Xiaobo Sun
  • Special Issue
  • - Volume 2020
  • - Article ID 5609637
  • - Research Article

Hypoxia-Induced Glioma-Derived Exosomal miRNA-199a-3p Promotes Ischemic Injury of Peritumoral Neurons by Inhibiting the mTOR Pathway

Jian-Lan Zhao | Bo Tan | ... | Rong Xie
  • Special Issue
  • - Volume 2020
  • - Article ID 1201624
  • - Research Article

Cholic Acid Protects In Vitro Neurovascular Units against Oxygen and Glucose Deprivation-Induced Injury through the BDNF-TrkB Signaling Pathway

Changxiang Li | Xueqian Wang | ... | Qingguo Wang
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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