Oxidative Medicine and Cellular Longevity

Applications of Antioxidants in Metabolic Disorders and Degenerative Diseases: Mechanistic Approach


Publishing date
01 Apr 2019
Status
Published
Submission deadline
30 Nov 2018

1Suez Canal University, Ismailia, Egypt

2Cairo University, Giza, Egypt

3University of Oradea, Oradea, Romania

4Polish Academy of Sciences, Jastrzebiec, Poland


Applications of Antioxidants in Metabolic Disorders and Degenerative Diseases: Mechanistic Approach

Description

Reactive oxygen species (ROS) are highly reactive molecules which induce oxidative damage to cellular macromolecules including nucleic acids, protein, peptides, and lipids, leading to metabolic disorders and degenerative disorders.

Oxidative stress plays an important role in the pathogenesis of many metabolic disorders and degenerative diseases, including diabetes, atherosclerosis, cancer, Alzheimer's, Parkinsonism, hypertension, stroke, rheumatoid arthritis, and inflammatory bowel disease in human and animals. On the contrary, antioxidants have a plethora of biomedical values and could be used for prevention and treatment of many oxidative damage-related disorders and diseases. Many metabolic disorders and degenerative diseases could be studied under laboratory conditions as models induced by certain drugs and toxicants involvingexcessive ROS production.

Understanding the molecular targets of antioxidants as well as associated disease pathogenesis remains the primary target of many researchers aiming for the characterization of optimum preventive and therapeutic interventions.

This special issue is dedicated to integrating the previous and the current use of antioxidants to counteract metabolicdisorders and degenerative diseases. We cordially invite investigators to contribute their original and review articles in our special issue.

Potential topics include but are not limited to the following:

  • Isolation, characterization, and pharmacological evaluation of novel antioxidants
  • Potential oxidative stress biomarkers in signal transduction pathways of metabolic disorders and degenerative diseases
  • The implication of antioxidants in prevention and treatment of metabolic disorders
  • Prophylactic and therapeutic applications of antioxidant for prevention and treatment of degenerative diseases
  • Antioxidants roles in chemically induced disease models (of cancer, diabetes, rheumatoid arthritis, atherosclerosis, or neurodegenerative disorders)
  • The therapeutic application of antioxidants against aging and age-related diseases

Articles

  • Special Issue
  • - Volume 2019
  • - Article ID 4179676
  • - Editorial

Applications of Antioxidants in Metabolic Disorders and Degenerative Diseases: Mechanistic Approach

Mohamed M. Abdel-Daim | Osama S. El-Tawil | ... | Atanas G. Atanasov
  • Special Issue
  • - Volume 2019
  • - Article ID 3984906
  • - Research Article

Suppression of Alzheimer’s Disease-Like Pathology Progression by Mitochondria-Targeted Antioxidant SkQ1: A Transcriptome Profiling Study

Natalia A. Stefanova | Nikita I. Ershov | Nataliya G. Kolosova
  • Special Issue
  • - Volume 2019
  • - Article ID 8765954
  • - Review Article

SIRT1 Modulators in Experimentally Induced Liver Injury

Hassan Farghali | Mighty Kgalalelo Kemelo | Nikolina Kutinová Canová
  • Special Issue
  • - Volume 2019
  • - Article ID 8574386
  • - Research Article

Curcumin Inhibits the PERK-eIF2α-CHOP Pathway through Promoting SIRT1 Expression in Oxidative Stress-induced Rat Chondrocytes and Ameliorates Osteoarthritis Progression in a Rat Model

Kai Feng | Yuwei Ge | ... | Xiaoqing Wang
  • Special Issue
  • - Volume 2019
  • - Article ID 5360560
  • - Research Article

Encapsulated Mulberry Fruit Extract Alleviates Changes in an Animal Model of Menopause with Metabolic Syndrome

Jintanaporn Wattanathorn | Supannika Kawvised | Wipawee Thukham-mee
  • Special Issue
  • - Volume 2019
  • - Article ID 9475908
  • - Review Article

Antiangiogenic Effect of Alkaloids

Masoud Alasvand | Vahideh Assadollahi | ... | Ilaria Peluso
  • Special Issue
  • - Volume 2019
  • - Article ID 9752698
  • - Research Article

Endogenous CSE/Hydrogen Sulfide System Regulates the Effects of Glucocorticoids and Insulin on Muscle Protein Synthesis

Ruxia Wang | Kelin Li | ... | Hai Lin
  • Special Issue
  • - Volume 2019
  • - Article ID 8739730
  • - Research Article

Overexpression of BRCA1 in Neural Stem Cells Enhances Cell Survival and Functional Recovery after Transplantation into Experimental Ischemic Stroke

Pengfei Xu | Xiaolei Shi | ... | Gelin Xu
  • Special Issue
  • - Volume 2019
  • - Article ID 2745352
  • - Research Article

The Preventive Effects and the Mechanisms of Action of Navel Orange Peel Hydroethanolic Extract, Naringin, and Naringenin in N-Acetyl-p-aminophenol-Induced Liver Injury in Wistar Rats

Osama M. Ahmed | Hanaa I. Fahim | ... | Walaa H. Abdelazeem
  • Special Issue
  • - Volume 2019
  • - Article ID 9417498
  • - Research Article

Syzygium cumini Leaf Extract Reverts Hypertriglyceridemia via Downregulation of the Hepatic XBP-1s/PDI/MTP Axis in Monosodium L-Glutamate-Induced Obese Rats

Lucas Martins França | Caio Fernando Ferreira Coêlho | ... | Antonio Marcus de Andrade Paes
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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