Reactive oxygen species (ROS) are highly reactive molecules which induce oxidative damage to cellular macromolecules including nucleic acids, protein, peptides, and lipids, leading to metabolic disorders and degenerative disorders.

Oxidative stress plays an important role in the pathogenesis of many metabolic disorders and degenerative diseases, including diabetes, atherosclerosis, cancer, Alzheimer's, Parkinsonism, hypertension, stroke, rheumatoid arthritis, and inflammatory bowel disease in human and animals. On the contrary, antioxidants have a plethora of biomedical values and could be used for prevention and treatment of many oxidative damage-related disorders and diseases. Many metabolic disorders and degenerative diseases could be studied under laboratory conditions as models induced by certain drugs and toxicants involvingexcessive ROS production.

Understanding the molecular targets of antioxidants as well as associated disease pathogenesis remains the primary target of many researchers aiming for the characterization of optimum preventive and therapeutic interventions.

This special issue is dedicated to integrating the previous and the current use of antioxidants to counteract metabolicdisorders and degenerative diseases. We cordially invite investigators to contribute their original and review articles in our special issue.

Potential topics include but are not limited to the following:

• Isolation, characterization, and pharmacological evaluation of novel antioxidants
• Potential oxidative stress biomarkers in signal transduction pathways of metabolic disorders and degenerative diseases
• The implication of antioxidants in prevention and treatment of metabolic disorders
• Prophylactic and therapeutic applications of antioxidant for prevention and treatment of degenerative diseases
• Antioxidants roles in chemically induced disease models (of cancer, diabetes, rheumatoid arthritis, atherosclerosis, or neurodegenerative disorders)
• The therapeutic application of antioxidants against aging and age-related diseases