Antioxidants and Cancer: Theories, Techniques, and Trials in Preventing Cancer
1Columbia University Medical Center, New York, USA
2Universidad Autónoma de Madrid, Madrid, Spain
3City University of New York, Bronx, USA
4University of Alberta, Edmonton, Canada
5University of Chile, Santiago, Chile
Antioxidants and Cancer: Theories, Techniques, and Trials in Preventing Cancer
Description
The interaction between reactive O2 species (ROS) and inflammasome plays a crucial role in the pathogenesis of oncological and nononcological diseases. Preclinical and clinical studies are flourishing worldwide to support some theories of anticancer preventive strategy using antioxidants. The advancements in biotechnology are transforming the way we diagnose and cure diseases. Recently, a historic moment for the noncommunicable disease community has been reached because world leaders formally adopted the 2030 Agenda for Sustainable Development at the United Nations in New York (USA) with 17 sustainable development goals and 169 targets that will drive efforts to improve health and well-being and protect our planet over the next fifteen years. Trials are being registered and conducted in the clinical community to identify molecules that will be useful for future therapeutic professional guidelines. There is a need of novel, more specific antioxidant and anti-inflammatory approaches aimed at prevention of ROS formation by targeting specific molecular pathways involved in ROS generation and, specifically, their activation of proinflammatory cascades. Oxidative stress can cause arrest or induction of transcription, activation of signaling pathways, and genomic instability. These molecules are key factors that modulate cancer cell proliferation, evasion of apoptosis, contiguous tumor spreading, epithelial mesenchymal transition, tumor angiogenesis, and metastasis.
In this special issue, we are interested in receiving original investigations as well as authoritative narrative or systematic review with or without PRISMA-guided meta-analysis which describe new modalities for strategies in animal models and at clinical level in terms of prevention, diagnosis, and treatment.
Potential topics include but are not limited to the following:
- ChIP-sequencing
- Nanoscale trials
- Analytical chemistry of macromolecules
- Cancer stem cells driven resistance to chemotherapy for both hematologic cancer and solid cancer
- ROS, antioxidants
- Autophagy-modulating mechanisms and drugs
- Mitophagy nanoregulators
- Sirtuins-modulators
- Exploring or discussing the concepts related to prevention and those key factors that modulate the hallmarks of cancer from stem cells to metastasis