Oxidative Medicine and Cellular Longevity

Oxidative Stress and Pulmonary Diseases: Signaling Pathways and Therapeutic Implication 2021


Publishing date
01 Jul 2022
Status
Closed
Submission deadline
25 Feb 2022

1Oswaldo Cruz Institute, Rio de Janeiro, Brazil

2Federal University of Alagoas, Maceió, Brazil

3University of Lyon, Marcy-l'Étoile, France

4Université de Rennes 1, Rennes, France

This issue is now closed for submissions.
More articles will be published in the near future.

Oxidative Stress and Pulmonary Diseases: Signaling Pathways and Therapeutic Implication 2021

This issue is now closed for submissions.
More articles will be published in the near future.

Description

In homeostasis, the production of cellular reactive oxygen species (ROS) is generated endogenously during mitochondrial oxidative metabolism. An arsenal of local antioxidant enzymes such as catalase, superoxide dismutase, and glutathione peroxidase controls ROS levels. ROS products by normal cell metabolism are crucial to cell homeostasis maintenance, particularly for its role in immunocompetence and activation of several signal transduction pathways.

In the uncontrolled inflammatory response, ROS overwhelm the cellular antioxidant defense system, resulting in direct or indirect ROS-mediated damage of nucleic acids, proteins, and lipids. In the acute inflammatory process, high intracellular levels of ROS have been implicated in an impairment of resolution of inflammation and cellular injury, resulting in chronic inflammation. The imbalance due to excess ROS or oxidants reduces the ability of the cell to mount an effective antioxidant response and is implicated in airway and lung inflammatory diseases.

This Special Issue invites investigators to submit original research articles that aim to increase our knowledge about the oxidative stress-associated mechanisms, signaling pathways, and corresponding therapeutics in the pathogenesis and treatment of acute or chronic lung diseases.

Potential topics include but are not limited to the following:

  • ROS signaling pathway as central component of maintenance of homeostasis
  • Role of oxidative stress in resolution of inflammation
  • Role of oxidative stress in acute or chronic inflammation
  • Effects of old and newest compounds on lung inflammatory diseases
Oxidative Medicine and Cellular Longevity
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Acceptance rate33%
Submission to final decision83 days
Acceptance to publication26 days
CiteScore9.300
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Impact Factor7.310
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Article of the Year Award: Outstanding research contributions of 2021, as selected by our Chief Editors. Read the winning articles.