Oxidative Medicine and Cellular Longevity

Role of SIRT1-Mediated Reactive Oxygen Species and Neuroinflammation in Stroke


Publishing date
01 Dec 2022
Status
Closed
Submission deadline
15 Jul 2022

Guest Editors

1Beijing Friendship Hospital, Beijing, China

2Johns Hopkins University, Baltimore, USA

3Jinling Hospital Medical School of Nanjing University, Nanjing, China

4Nanjing Drum Tower Hospital, Nanjing, China

This issue is now closed for submissions.

Role of SIRT1-Mediated Reactive Oxygen Species and Neuroinflammation in Stroke

This issue is now closed for submissions.

Description

A stroke is a fatal cerebral vascular disease with high morbidity and mortality rate in most countries. With the occurrence of hemorrhage and ischemia, reactive oxygen species (ROS) overproduction and neuroinflammation have been implicated in the subsequent brain injury. ROS can elicit a plethora of detrimental effects on cellular functions by causing damages to proteins, lipids, and nucleic acids. In addition, ROS overproduction is closely associated with neuroinflammation and each of them promotes and amplifies the other one. Therefore, there is a pressing need to find new therapeutic targets for stroke.

SIRT1, a member of the sirtuin family, plays a prominent role in regulating various biological functions, such as immune response, apoptosis, oxidative stress, and aging. The function of SIRT1 is increasingly recognized as especially important in the pathogenesis of neurological diseases. At the cellular level, SIRT1 is known as a nuclear protein, which is predominantly expressed in neurons. Upon activation, SIRT1 can modulate a variety of signaling pathways to affect oxidative stress and inflammation, including nuclear factor-erythroid 2-related factor 2, nod-like receptor pyrin domain-containing 3 inflammasome, forkhead transcription factors of the O class, and NADPH oxidases. Targeting the SIRT1 to reduce ROS and neuroinflammation might represent an emerging therapeutic target for stroke. However, the current therapeutics studies always ignore the crosstalk between ROS and neuroinflammation mediated by SIRT1.

The aim of this Special Issue is to collate original research and review articles about the SIRT1-mediated mechanisms, signaling pathways, and corresponding therapeutics in oxidative stress and neuroinflammation after stroke.

Potential topics include but are not limited to the following:

  • Novel underlying mechanisms of SIRT1 in the pathophysiological processes of stroke
  • The interplay between ROS and neuroinflammation
  • Effect of compounds and natural drugs on SIRT1 signaling related to oxidative stress and neuroinflammation
  • New therapeutic strategies targeting oxidative stress and neuroinflammation for the treatment of stroke
  • Translational research for the treatment of strokes related to SIRT1 signaling

Articles

  • Special Issue
  • - Volume 2023
  • - Article ID 7733857
  • - Research Article

Premorbid Use of Beta-Blockers or Angiotensin-Converting Enzyme Inhibitors/Angiotensin Receptor Blockers in Patients with Acute Ischemic Stroke

Yuanyuan Zeng | Kelin Nie | ... | Chao Jiang
  • Special Issue
  • - Volume 2022
  • - Article ID 3550204
  • - Research Article

Pterostilbene Attenuates Subarachnoid Hemorrhage-Induced Brain Injury through the SIRT1-Dependent Nrf2 Signaling Pathway

Zihuan Zhang | Jincheng Fang | ... | Yue Lu
  • Special Issue
  • - Volume 2022
  • - Article ID 2242833
  • - Research Article

Activation of Sirtuin-1 by Pinocembrin Treatment Contributes to Reduced Early Brain Injury after Subarachnoid Hemorrhage

Yile Zeng | Zhongning Fang | ... | Xiangrong Chen
  • Special Issue
  • - Volume 2022
  • - Article ID 3119649
  • - Research Article

Docosahexaenoic Acid Alleviates Brain Damage by Promoting Mitophagy in Mice with Ischaemic Stroke

Eryi Sun | Jing Zhang | ... | Bo Chen
  • Special Issue
  • - Volume 2022
  • - Article ID 3948921
  • - Review Article

Molecular, Pathological, Clinical, and Therapeutic Aspects of Perihematomal Edema in Different Stages of Intracerebral Hemorrhage

Chao Jiang | Hengtao Guo | ... | Jian Wang
  • Special Issue
  • - Volume 2022
  • - Article ID 1949718
  • - Review Article

Natural Compounds for SIRT1-Mediated Oxidative Stress and Neuroinflammation in Stroke: A Potential Therapeutic Target in the Future

Chaoyou Fang | Houshi Xu | ... | Meiqing Lou
  • Special Issue
  • - Volume 2022
  • - Article ID 9069825
  • - Research Article

Activation of SIRT1 Alleviates Ferroptosis in the Early Brain Injury after Subarachnoid Hemorrhage

Bin Yuan | Xu-Dong Zhao | ... | Qi Wu
  • Special Issue
  • - Volume 2022
  • - Article ID 3345637
  • - Review Article

Biological Effects and Mechanisms of Caspases in Early Brain Injury after Subarachnoid Hemorrhage

Yiwen Wu | Yuchun Liu | ... | Yi Huang
  • Special Issue
  • - Volume 2022
  • - Article ID 3099409
  • - Research Article

Cycloastragenol Confers Cerebral Protection after Subarachnoid Hemorrhage by Suppressing Oxidative Insults and Neuroinflammation via the SIRT1 Signaling Pathway

Weibin Lin | Hao Yao | ... | Xiangrong Chen
Oxidative Medicine and Cellular Longevity
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