Oxidative Medicine and Cellular Longevity

Biomarkers of Oxidative Stress in Experimental Models and Human Studies with Nutraceuticals: Measurement, Interpretation, and Significance


Status
Published

Lead Editor

1Centre of the Agricultural Research Council (CRA-NUT), Rome, Italy

2University of Rome, Rome, Italy

3Institute of Food Science, Technology and Nutrition (ICTAN-CSIC), Madrid, Spain

4Bio & Nano-Solutions, Bielefeld, Germany


Biomarkers of Oxidative Stress in Experimental Models and Human Studies with Nutraceuticals: Measurement, Interpretation, and Significance

Description

Oxidative stress, the imbalance between reactive oxygen species (ROS) formation and enzymatic and nonenzymatic antioxidants, is involved in the pathogenesis and progression of many ageing-associated diseases, such as cardiovascular disease and certain forms of cancer and neurodegenerative diseases. Most importantly, the chronic low grade inflammation associated with metabolic syndrome is characterized by a chronic oxidative stress condition. ROS originate either from exogenous agents, such as environmental pollutants and cigarette smoke, or from endogenous sources, such as mitochondrial respiratory chain leakage or oxidative killing of bacteria by activated phagocytes. Furthermore, oxidative stress is distinctly involved in the toxicity of many drugs. In the defence against ROS, both enzymatic and nonenzymatic antioxidants produced by cells and the low molecular weight molecules absorbed from food stuffs play a vital role. An increasing body of evidence shows that some natural functional ingredients would be beneficial to human health. Consequently, a significant research effort focused on the determination of the antioxidant capacity of natural products and their mode of antioxidant action, as well as secondary or cascade effects, such as activation of human endogenous antioxidant systems or interaction with intestinal microbiota.

With a continually growing (bio)medical interest in the (patho)biology of oxidative stress and the potential bioremedial effects of natural functional components (nutraceuticals), such as nutritional and herbal antioxidants and pro- and prebiotics, numerous assays and in vitro and animal models have been developed over the past decades. Furthermore, oxidative stress markers are important tools to assess both the redox status of subjects and the health-enhancing effects of antioxidants in humans. Unfortunately, there is a lack of consensus, analytical validation, standardization, and reproducibility regarding many oxidative stress markers, evaluation models, and antioxidant assays. In addition, normal ranges for these markers should be established in order to allow comparison between studies without the risk of misinterpretation of results.

In this special issue, we invite investigators to contribute original research articles based on both experimental and clinical data, short or comprehensive reviews, and perspective articles that shed light on the meaning of oxidative markers stress and the bioremedial capacity of natural functional components in experimental models and human studies.

Potential topics include, but are not limited to:

  • Methods of evaluation of oxidative stress in humans and their relevance in diagnosis and prognosis of human diseases
  • Animal or experimental models of oxidative stress-related diseases
  • Studies involving human models of acute inflammation and oxidative stress such as metabolic overload (oral glucose or lipids) or strenuous exercise
  • Human, animal, or in vitro studies evaluating the effects of natural functional ingredients in relation to oxidative stress
  • Human, animal, or in vitro studies measuring enzymatic and nonenzymatic antioxidants, total antioxidant capacity, and markers of oxidative damage to biological macromolecules such as DNA, lipids, carbohydrates, and proteins
  • Human, animal, or in vitro studies measuring redox-modulated gene expression and free radicals production

Topics that will not be covered in this special issue include:

Chemical characterization of foods/natural products/ingredients/extracts and/or in vitro evaluation of antioxidant capacity not including any determination in experimental models (cell cultures, isolated tissues, or perfused organs will be accepted as experimental model) or humans.


Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 6159810
  • - Editorial

Biomarkers of Oxidative Stress in Experimental Models and Human Studies with Nutraceuticals: Measurement, Interpretation, and Significance

Ilaria Peluso | Maura Palmery | ... | Gregor Drummen
  • Special Issue
  • - Volume 2016
  • - Article ID 9191407
  • - Research Article

Preexposure to Olive Oil Polyphenols Extract Increases Oxidative Load and Improves Liver Mass Restoration after Hepatectomy in Mice via Stress-Sensitive Genes

Jelena Marinić | Dalibor Broznić | Čedomila Milin
  • Special Issue
  • - Volume 2016
  • - Article ID 5264064
  • - Research Article

Changes in Oxidative Stress and Antioxidant Enzyme Activities in Streptozotocin-Induced Diabetes Mellitus in Rats: Role of Alhagi maurorum Extracts

S. A. Sheweita | S. Mashaly | ... | S. M. Eweda
  • Special Issue
  • - Volume 2016
  • - Article ID 1746985
  • - Research Article

Validation of a Reversed-Phase High Performance Liquid Chromatography Method for the Simultaneous Analysis of Cysteine and Reduced Glutathione in Mouse Organs

Serena Brundu | Lucia Nencioni | ... | Alessandra Fraternale
  • Special Issue
  • - Volume 2016
  • - Article ID 7174351
  • - Research Article

Antioxidant Potential of Spirulina platensis Mitigates Oxidative Stress and Reprotoxicity Induced by Sodium Arsenite in Male Rats

Samir A. E. Bashandy | Sally A. El Awdan | ... | Ibrahim M. Alhazza
  • Special Issue
  • - Volume 2016
  • - Article ID 2427618
  • - Research Article

Dietary Phenolic Compounds Interfere with the Fate of Hydrogen Peroxide in Human Adipose Tissue but Do Not Directly Inhibit Primary Amine Oxidase Activity

Christian Carpéné | Mounia Hasnaoui | ... | Maria P. Portillo
  • Special Issue
  • - Volume 2016
  • - Article ID 2572606
  • - Research Article

Effects of Polyphenol, Measured by a Biomarker of Total Polyphenols in Urine, on Cardiovascular Risk Factors After a Long-Term Follow-Up in the PREDIMED Study

Xiaohui Guo | Anna Tresserra-Rimbau | ... | Rosa M. Lamuela-Raventós
  • Special Issue
  • - Volume 2016
  • - Article ID 1594616
  • - Research Article

The Potential Health Benefits of Polyphenol-Rich Extracts from Cichorium intybus L. Studied on Caco-2 Cells Model

Elena Azzini | Giuseppe Maiani | ... | Fabio Nobili
  • Special Issue
  • - Volume 2016
  • - Article ID 5630985
  • - Clinical Study

Relationship between the Peroxidation of Leukocytes Index Ratio and the Improvement of Postprandial Metabolic Stress by a Functional Food

Ilaria Peluso | Husseen Manafikhi | ... | Maura Palmery
  • Special Issue
  • - Volume 2016
  • - Article ID 2827567
  • - Research Article

Administration of a Polyphenol-Enriched Feed to Farmed Sea Bass (Dicentrarchus labrax L.) Modulates Intestinal and Spleen Immune Responses

Thea Magrone | Sergio Fontana | ... | Letizia Passantino
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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