Oxidative Medicine and Cellular Longevity

Modulation of Redox Signaling in Chronic Diseases and Regenerative Medicine


Publishing date
01 Nov 2018
Status
Published
Submission deadline
06 Jul 2018

1Federico II University, Naples, Italy

2University of Turin, Turin, Italy

3International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy

4University of Florence, Florence, Italy


Modulation of Redox Signaling in Chronic Diseases and Regenerative Medicine

Description

In the last decades, major advances in therapeutic strategies for chronic diseases have significantly reduced death rates. Redox signaling is being implicated in the pathophysiology of such diseases, affecting most organs. Proliferation of cancer cells, damage to cardiomyocytes and vascular cells, exacerbation of inflammation are just a few examples of events importantly controlled by reacting oxygen species (ROS). Physiologic levels of ROS act as signaling molecules and modulate healthy functions, while high levels of ROS can derange the homeostasis of most organs and systems in our body. Hence, fine-tuning the complexity of redox signaling is a very up-to-date field of research.

We invite authors to contribute original research articles that illustrate and stimulate the growing efforts to understand the implication of redox signaling in chronic diseases, such as cancer, inflammatory diseases, and cardiovascular diseases, as well as review articles that describe the current state of the art.

We are interested in articles describing new molecular players of oxidative stress as well as new approaches to manipulate ROS-driven processes for the treatment of these diseases and for the advancement of regenerative and rejuvenation approaches.

Potential topics include but are not limited to the following:

  • Role of oxidative stress in cancer, including redox-mediated pathways that promote proliferation and potential therapeutic implications in cancer therapy
  • Role of oxidative stress in anticancer drug-induced cardiotoxicity, including cardiac dysfunction, but also myocardial ischemia, arrhythmias, thromboembolism, arterial and pulmonary hypertension, and peripheral arterial occlusive disease
  • Role of oxidative stress in cardiovascular disease, not limited to ischemic heart disease, but also in hypertrophy and heart failure, valvular heart disease, cardiac aging and rejuvenation, cardiopulmonary diseases, including pulmonary hypertension
  • Role of ROS signaling in the recruitment of inflammatory cells and modulation of inflammation in immunologic and rheumatologic diseases
  • Identification of new signaling pathways/players implicated in ROS production in the healthy state and in the pathophysiology of the above-mentioned diseases
  • Identification of new potential tools to manipulate oxidative signaling for therapeutic purposes in the treatment of these diseases

Articles

  • Special Issue
  • - Volume 2019
  • - Article ID 6091587
  • - Editorial

Modulation of Redox Signaling in Chronic Diseases and Regenerative Medicine

Serena Zacchigna | Laura Sartiani | ... | Carlo G. Tocchetti
  • Special Issue
  • - Volume 2019
  • - Article ID 2867516
  • - Review Article

Use of Exogenous and Endogenous Photomediators as Efficient ROS Modulation Tools: Results and Perspectives for Therapeutic Purposes

Maria Rosa Antognazza | Ilaria Abdel Aziz | Francesco Lodola
  • Special Issue
  • - Volume 2019
  • - Article ID 5813147
  • - Review Article

Adult Cardiac Stem Cell Aging: A Reversible Stochastic Phenomenon?

Eleonora Cianflone | Michele Torella | ... | Daniele Torella
  • Special Issue
  • - Volume 2019
  • - Article ID 8912768
  • - Research Article

Dipeptidyl Peptidase 4 Inhibition Ameliorates Chronic Kidney Disease in a Model of Salt-Dependent Hypertension

Donato Cappetta | Loreta Pia Ciuffreda | ... | Konrad Urbanek
  • Special Issue
  • - Volume 2018
  • - Article ID 9582319
  • - Research Article

Parathyroid Hormone Causes Endothelial Dysfunction by Inducing Mitochondrial ROS and Specific Oxidative Signal Transduction Modifications

Jessica Gambardella | Matteo De Rosa | ... | Guido Iaccarino
  • Special Issue
  • - Volume 2018
  • - Article ID 6816508
  • - Research Article

β3-Adrenoreceptors Control Mitochondrial Dormancy in Melanoma and Embryonic Stem Cells

Maura Calvani | Lorenzo Cavallini | ... | Luca Filippi
  • Special Issue
  • - Volume 2018
  • - Article ID 6510159
  • - Research Article

Photobiomodulation at Multiple Wavelengths Differentially Modulates Oxidative Stress In Vitro and In Vivo

Katia Rupel | Luisa Zupin | ... | Serena Zacchigna
  • Special Issue
  • - Volume 2018
  • - Article ID 6054361
  • - Research Article

Nox2 Activity Is Required in Obesity-Mediated Alteration of Bone Remodeling

Md Mizanur Rahman | Amina El Jamali | ... | Gianfranco Pintus
  • Special Issue
  • - Volume 2018
  • - Article ID 5801807
  • - Research Article

A Novel Small Peptide Inhibitor of NFκB, RH10, Blocks Oxidative Stress-Dependent Phenotypes in Cancer

Jessica Gambardella | Michele Ciccarelli | ... | Daniela Sorriento
  • Special Issue
  • - Volume 2018
  • - Article ID 2639081
  • - Research Article

Antioxidant Activity Mediates Pirfenidone Antifibrotic Effects in Human Pulmonary Vascular Smooth Muscle Cells Exposed to Sera of Idiopathic Pulmonary Fibrosis Patients

Alessandro Giuseppe Fois | Anna Maria Posadino | ... | Gianfranco Pintus
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision74 days
Acceptance to publication36 days
CiteScore4.520
Impact Factor4.868
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