Oxidative Medicine and Cellular Longevity

Molecular Mechanisms of Natural Antioxidant Compounds with Neuroprotective Effects


Publishing date
01 Oct 2019
Status
Closed
Submission deadline
31 May 2019

1Polytechnic Institute of Bragança, Bragança, Portugal

2University of Porto, Porto, Portugal

3State University of Maringá, Maringá, Brazil

This issue is now closed for submissions.
More articles will be published in the near future.

Molecular Mechanisms of Natural Antioxidant Compounds with Neuroprotective Effects

This issue is now closed for submissions.
More articles will be published in the near future.

Description

The search for natural compounds with potential health benefits is increasingly important, attaining special relevance when focused on diseases with alarmingly growing rates, such as neurodegenerative diseases. For example, Alzheimer’s disease (AD) is expected to affect more than 100 million individuals by 2050, while neurodegenerative diseases in general are estimated to surpass cancer as the second cause of death among elderly by 2040.

Neuropathology is often related to oxidative stress, inflammatory response, and neurotoxic factors. Common synthetic drugs against neurodegenerative diseases often involve acetylcholinesterase and—to a lesser extent—butyrylcholinesterase inhibitors. However, these therapeutic agents do not alter the disease course substantially enough and either are associated with critical side effects, such as depletion of the neurotransmitter substrate and an altered response in the surviving neurons, or lose their effectiveness after extended use.

Natural compounds with pharmacological and antioxidant activities might be suitable candidates for neuroprotective purposes. In fact, natural bioactive compounds, such as sterols, phlorotannins, carotenoids, or sulphated polysaccharides, have previously been reported as having this particular type of bioactivity. However, their in vivo activity is often limited by their limited bioavailability and their insufficient delivery to the brain.

This special issue welcomes original research and review articles focusing on the molecular mechanism of action of natural-based antioxidant compounds and the development of effective delivery systems to improve their bioavailability.

Potential topics include but are not limited to the following:

  • Natural sources of bioactive compounds with neuroprotective effect
  • Antioxidant potential of plants
  • Therapeutic potential of medicinal mushrooms for the management of neurodegenerative disease
  • Antioxidant activities of algae
  • Emerging extraction techniques of bioactive compounds for potential application in neuroprotection
  • Purification and structural elucidation of targeted bioactive compounds with antioxidant, anti-inflammatory, and cytotoxic properties
  • Structure-activity relationship of neuroprotective compounds
  • Biosynthetic pathways
  • Protected delivery mechanisms
  • In vitro, ex vivo, or in vivo evaluation of neuroprotective effects
  • Antioxidant activity
  • Neuroprotective assays in cell lines
  • Cognitive tests

Articles

  • Special Issue
  • - Volume 2020
  • - Article ID 9741369
  • - Research Article

Metformin Promotes Axon Regeneration after Spinal Cord Injury through Inhibiting Oxidative Stress and Stabilizing Microtubule

Haoli Wang | Zhilong Zheng | ... | Jian Xiao
  • Special Issue
  • - Volume 2019
  • - Article ID 8409329
  • - Review Article

Mitochondrial Dysfunction and Alpha-Lipoic Acid: Beneficial or Harmful in Alzheimer’s Disease?

Sávio Monteiro dos Santos | Camila Fernanda Rodrigues Romeiro | ... | Marta Chagas Monteiro
  • Special Issue
  • - Volume 2019
  • - Article ID 2053149
  • - Research Article

CGRP Reduces Apoptosis of DRG Cells Induced by High-Glucose Oxidative Stress Injury through PI3K/AKT Induction of Heme Oxygenase-1 and Nrf-2 Expression

YaDong Liu | SiCong Zhang | ... | LiuCheng Ding
  • Special Issue
  • - Volume 2019
  • - Article ID 1652609
  • - Research Article

Differential Effects of Silibinin A on Mitochondrial Function in Neuronal PC12 and HepG2 Liver Cells

Carsten Esselun | Bastian Bruns | ... | Gunter P. Eckert
  • Special Issue
  • - Volume 2019
  • - Article ID 3642491
  • - Review Article

The Importance of Natural Antioxidants in the Treatment of Spinal Cord Injury in Animal Models: An Overview

Angélica Coyoy-Salgado | Julia J. Segura-Uribe | ... | Carlos E. Orozco-Barrios
  • Special Issue
  • - Volume 2019
  • - Article ID 7850154
  • - Research Article

Neuroprotective Effect of SCM-198 through Stabilizing Endothelial Cell Function

Qiu-Yan Zhang | Zhi-Jun Wang | ... | Yi-Zhun Zhu
  • Special Issue
  • - Volume 2019
  • - Article ID 1479571
  • - Research Article

A Solid Dispersion of Quercetin Shows Enhanced Nrf2 Activation and Protective Effects against Oxidative Injury in a Mouse Model of Dry Age-Related Macular Degeneration

Yan Shao | Haitao Yu | ... | Xinrong Xu
  • Special Issue
  • - Volume 2019
  • - Article ID 7860650
  • - Research Article

Dietary Supplementation of the Antioxidant Curcumin Halts Systemic LPS-Induced Neuroinflammation-Associated Neurodegeneration and Memory/Synaptic Impairment via the JNK/NF-κB/Akt Signaling Pathway in Adult Rats

Muhammad Sohail Khan | Tahir Muhammad | ... | Myeong Ok Kim
  • Special Issue
  • - Volume 2019
  • - Article ID 8416105
  • - Research Article

Sailuotong Capsule Prevents the Cerebral Ischaemia-Induced Neuroinflammation and Impairment of Recognition Memory through Inhibition of LCN2 Expression

Yehao Zhang | Jianxun Liu | ... | Hao Li
  • Special Issue
  • - Volume 2019
  • - Article ID 8549727
  • - Research Article

Effect of Zinc on the Oxidative Stress Biomarkers in the Brain of Nickel-Treated Mice

Jurgita Šulinskienė | Rasa Bernotienė | ... | Leonid Ivanov
Oxidative Medicine and Cellular Longevity
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