Lipid metabolism in the intestine, the first step of lipid processing before absorption, is pivotal in maintaining whole-body metabolic health. The intestine is a complex and dynamic ecosystem mainly composed of chyme and microbes which functions as a regulator and barrier for other metabolic organs.

Currently, the research on lipid metabolism by intestinal microbes and epithelial cells, as well as the role of lipids and related molecules secreted by metabolic organs (adipose tissue, muscle, and liver) in digestive physiology, is relatively underdeveloped. Metabolism comes with oxidative stress, such as lipid oxidation. Thus, it is necessary to improve our understanding of the whole processes of lipid metabolism and oxidative stress within in the gut and other metabolic organs.

This Special Issue aims to encourage authors to submit original research and review articles related to the role of lipid metabolism and oxidative stress in the intestine and other metabolic organs, and molecular mechanisms connecting lipid metabolism and oxidative stress. In addition, studies discussing specific nutrients that act as regulators of gut microbiota and are designed for the prevention of metabolic diseases and their ramifications are also welcome. Identifying natural products derived from microbiota metabolism which may serve as indicators of oxidative stress, as well as new methods to track the transportation of nutrients in metabolic organs and new genetic or nutritional strategies for maintaining homeostasis of gut and other metabolic organs in experimental animals and humans, are also of interest.

Potential topics include but are not limited to the following:

• Lipid metabolism in intestinal epithelial cells
• Lipid metabolism in the lumen of the intestine
• Host-microbe metabolic interaction: specific nutrients acting as regulators of gut microbiota in oxidative stress
• Microbiota metabolites function during lipid peroxidation reactions: assessing the role of lipid peroxidative damage in the pathogenesis of metabolic disease
• Lipid oxidation, ferroptosis, and organ injury
• Crosstalk between adipogenesis and myogenesis in skeletal muscle and its contribution to metabolic homeostasis
• Endocrinal role of adipose tissue and muscle in the digestive tract