Oxidative Medicine and Cellular Longevity

Natural Bioactive Products with Antioxidant Properties Useful in Neurodegenerative Diseases


Publishing date
01 Feb 2019
Status
Published
Submission deadline
05 Oct 2018

1State University of Paraíba, Campina Grande, Brazil

2Federal University of Paraíba, João Pessoa, Brazil

3Vellore Institute of Technology, Tamil Nadu, India

4University of Yaoundé I, Yaoundé, Cameroon


Natural Bioactive Products with Antioxidant Properties Useful in Neurodegenerative Diseases

Description

Neurodegenerative diseases (NDs) constitute a large group of pathological conditions, characterized by a progressive loss of neuronal cells, which compromises motor and/or cognitive functions. The most common NDs are Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), Parkinson’s disease (PD), and Huntington’s disease (HD). The causes of these pathologies are multifactorial and not fully understood, but it is well known that factors related to aging and to the overproduction of free radical and reactive oxygen species lead to oxidative stress and to cell death, which are extremely related. Whereas oxidative stress plays an unquestionable and central role in the NDs, the control of free radicals and reactive oxygen species levels represents an interesting and promising strategy to delay neurodegeneration and attenuate the associated symptoms.

In this context, several natural bioactive compounds isolated from plants, fungi, and algae, among others, and also synthetic compounds inspired by natural scaffolds, which presents antioxidant properties, including vitamins C and E, anthocyanins, and phenolic compounds (flavonoids, coumarins, and polyphenols), are extensively described as potential palliative agents of neurodegenerative symptoms. In vitro and in vivo studies performed with extracts and fractions of plants and with isolated natural bioactive compounds evidence the role of these substances in the modulation of the cellular redox balance and in the reduction of the formation of reactive oxygen species originating from oxidative stress, demonstrating thus their great value as antioxidant agents and cellular protectors.

In this special issue, we invite researchers to contribute review articles as well as original research articles concerning the use of natural bioactive compounds (extracts, fractions, or isolated compounds) and related synthetic compounds with antioxidant properties, useful in preventing the symptoms of aging and neurodegenerative disorders.

Potential topics include but are not limited to the following:

  • Use of natural bioactive compounds (extracts, fractions, or isolated compounds) with antioxidant activity for the treatment of neurodegenerative pathologies
  • Foods with antioxidant properties capable of ameliorating neurodegenerative symptoms
  • Use of natural products as prototypes of new antioxidant drugs for the treatment of neurodegenerative diseases
  • Theoretical and computational studies in natural and synthetic bioactive compounds against neurodegenerative diseases
  • Studies of the cellular and molecular mechanisms associated with oxidative stress generated by natural and synthetic bioactive products in NDs
  • Pharmacological and toxicological effects of natural bioactive compounds: in vitro and in vivo studies of NDs
  • Clinical or preclinical studies showing bioactive compounds properties in the treatment of NDs
  • Technological strategies used to enhance the effects of bioactive compounds against NDs

Articles

  • Special Issue
  • - Volume 2019
  • - Article ID 7151780
  • - Editorial

Natural Bioactive Products with Antioxidant Properties Useful in Neurodegenerative Diseases

Francisco J. B. Mendonça-Junior | Marcus T. Scotti | ... | Luciana Scotti
  • Special Issue
  • - Volume 2019
  • - Article ID 2761041
  • - Research Article

Morinda citrifolia and Its Active Principle Scopoletin Mitigate Protein Aggregation and Neuronal Apoptosis through Augmenting the DJ-1/Nrf2/ARE Signaling Pathway

Kishore Kumar S. Narasimhan | Deepthy Jayakumar | ... | Kalaiselvi Periandavan
  • Special Issue
  • - Volume 2019
  • - Article ID 5046280
  • - Research Article

Pasteurized Orange Juice Rich in Carotenoids Protects Caenorhabditis elegans against Oxidative Stress and β-Amyloid Toxicity through Direct and Indirect Mechanisms

Ricardo Basílio de Oliveira Caland | Cesar Orlando Muñoz Cadavid | ... | Riva de Paula Oliveira
  • Special Issue
  • - Volume 2019
  • - Article ID 9421037
  • - Research Article

Ethanol Extract of Centipeda minima Exerts Antioxidant and Neuroprotective Effects via Activation of the Nrf2 Signaling Pathway

Yi-Jie Wang | Xin-Yue Wang | ... | Yong-Qiang Liu
  • Special Issue
  • - Volume 2019
  • - Article ID 3549274
  • - Research Article

Sulforaphane-Enriched Broccoli Sprouts Pretreated by Pulsed Electric Fields Reduces Neuroinflammation and Ameliorates Scopolamine-Induced Amnesia in Mouse Brain through Its Antioxidant Ability via Nrf2-HO-1 Activation

Lalita Subedi | KyoHee Cho | ... | Sun Yeou Kim
  • Special Issue
  • - Volume 2019
  • - Article ID 3640753
  • - Research Article

Inhibition of Oxidative Neurotoxicity and Scopolamine-Induced Memory Impairment by γ-Mangostin: In Vitro and In Vivo Evidence

Youngmun Lee | Sunyoung Kim | ... | Jungsook Cho
  • Special Issue
  • - Volume 2019
  • - Article ID 8673521
  • - Research Article

Eleutherococcus Species Cultivated in Europe: A New Source of Compounds with Antiacetylcholinesterase, Antihyaluronidase, Anti-DPPH, and Cytotoxic Activities

Kuba Adamczyk | Marta Olech | ... | Daniel Załuski
  • Special Issue
  • - Volume 2019
  • - Article ID 8639618
  • - Research Article

Honokiol-Mediated Mitophagy Ameliorates Postoperative Cognitive Impairment Induced by Surgery/Sevoflurane via Inhibiting the Activation of NLRP3 Inflammasome in the Hippocampus

Ji-Shi Ye | Lei Chen | ... | Zhong-Yuan Xia
  • Special Issue
  • - Volume 2019
  • - Article ID 9426867
  • - Review Article

Benefits of Vitamins in the Treatment of Parkinson’s Disease

Xiuzhen Zhao | Ming Zhang | ... | Ying Zhang
  • Special Issue
  • - Volume 2019
  • - Article ID 8204129
  • - Review Article

Antioxidant Properties of Amazonian Fruits: A Mini Review of In Vivo and In Vitro Studies

Raúl Avila-Sosa | Andrés Felipe Montero-Rodríguez | ... | Addí Rhode Navarro-Cruz
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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