Oxidative Medicine and Cellular Longevity

Nanoparticle-Induced Toxicities: an Update on the Role of Oxidative Stress


Publishing date
01 May 2022
Status
Published
Submission deadline
17 Dec 2021

1Univeristy of Kragujevac, Kragujevac, Serbia

2University of Kragujevac, Kragujevac, Serbia

3Witten/Herdecke University, Witten, Germany

4First Moscow State Medical University IM Sechenov, Moscow, Russia


Nanoparticle-Induced Toxicities: an Update on the Role of Oxidative Stress

Description

The interest in applications of new biomaterials, including a variety of nano-sized particles, has been increasing in medical disciplines. This is accompanied by the need for the estimation of adverse effects of such therapeutic approaches in a broad field of clinically targeted pathologies. At the same time, there has been confirmation of nanoparticle toxicities in numerous organs and tissues in widespread medical, so further elucidation of the general mechanism that may compromise their efficiency and safety is needed.

Preliminary reports have already confirmed the role of oxidative stress as one of the most common factors that lead to many adverse effects of nanoparticles. Even more, it has been noticed that oxidative damage may be the initial mechanism underlying some serious disadvantages for clinical indications that employ nano-sized particles, or it may trigger such mechanisms. Therefore, it seems appropriate to evaluate and promote the prevention of nanoparticle-induced toxicities by antioxidant supplementation. Moreover, there is a growing need for the antioxidant components from natural products and this can be complementary to these two current medical approaches (the employment of nanomaterials and simultaneous attenuation of their toxicities).

The aim of this Special Issue is to provide a comprehensive collection of both original research and review articles that focus on the estimation of oxidative stress as a key mechanism in many toxicities induced by nanoparticles. The presentation of data considering the prevention of toxicities induced by nanoparticles may increase enthusiasm for the use of these advanced materials along with the maintenance of the equilibrium of homeostatic mechanisms. We welcome submissions focusing either on the results obtained in preclinical studies or in clinical trials.

Potential topics include but are not limited to the following:

  • The use of nano-sized materials in medical therapeutic approaches
  • Oxidative damage as a principle mechanism of toxicities induced by nanomaterials
  • Antioxidant supplementation in prevention and treatment of nanoparticle-induced toxicities
  • Role of antioxidant-rich natural compounds in attenuation of pathologies correlated with nanoparticle-induced toxicities
  • Animal experimental models for the evaluation of oxidative damage in pathogenesis of nanoparticle-induced toxicities
  • Behavioral manifestations of neurotoxicity induced by nano-sized bone replacement materials – the role of antioxidant supplementation
  • The evaluation of systemic toxicities induced by nano-sized biomaterials – targeting oxidative damage mechanisms
  • Oxidative stress in the pathogenesis of toxicities induced by nanoparticles of plastic materials
  • Oxidative damage following the administration of nano-sized biomaterials in dentistry
  • Clinical trials for the evaluation of oxidative damage underlying nanoparticle-induced toxicities in global pollution

Articles

  • Special Issue
  • - Volume 2022
  • - Article ID 9895061
  • - Editorial

Nanoparticle-Induced Toxicities: An Update on the Role of Oxidative Stress

Gvozden Rosic | Dragica Selakovic
  • Special Issue
  • - Volume 2022
  • - Article ID 3483073
  • - Research Article

Comparative In Vitro Cytotoxicity Study of Carbon Dot-Based Organometallic Nanoconjugates: Exploration of Their Cell Proliferation, Uptake, and Localization in Cancerous and Normal Cells

Eepsita Priyadarshini | Ramovatar Meena | ... | Paulraj Rajamani
  • Special Issue
  • - Volume 2022
  • - Article ID 3863138
  • - Research Article

Exploring Dose-Dependent Cytotoxicity Profile of Gracilaria edulis-Mediated Green Synthesized Silver Nanoparticles against MDA-MB-231 Breast Carcinoma

Yugal Kishore Mohanta | Awdhesh Kumar Mishra | ... | Muthupandian Saravanan
  • Special Issue
  • - Volume 2022
  • - Article ID 3313016
  • - Review Article

Effects of Metal Oxide Nanoparticles in Zebrafish

Marta d’Amora | Tiziana Julia Nadjeschda Schmidt | ... | Francesco Tantussi
  • Special Issue
  • - Volume 2022
  • - Article ID 7969825
  • - Research Article

Evaluation of Zebrafish Toxicology and Biomedical Potential of Aeromonas hydrophila Mediated Copper Sulfide Nanoparticles

S. Rajeshkumar | J. Santhoshkumar | ... | Kalirajan Arunachalam
  • Special Issue
  • - Volume 2022
  • - Article ID 2079630
  • - Research Article

Exacerbation of Thrombotic Responses to Silver Nanoparticles in Hypertensive Mouse Model

Zannatul Ferdous | Sumaya Beegam | ... | Abderrahim Nemmar
  • Special Issue
  • - Volume 2021
  • - Article ID 7244677
  • - Review Article

An Overview of the Beneficial Role of Antioxidants in the Treatment of Nanoparticle-Induced Toxicities

Vladimir Mihailovic | Jelena S. Katanic Stankovic | ... | Gvozden Rosic
  • Special Issue
  • - Volume 2021
  • - Article ID 2990326
  • - Review Article

Combining Nanotechnology and Gas Plasma as an Emerging Platform for Cancer Therapy: Mechanism and Therapeutic Implication

Milad Rasouli | Nadia Fallah | Sander Bekeschus
  • Special Issue
  • - Volume 2021
  • - Article ID 3155962
  • - Review Article

Phytoantioxidant Functionalized Nanoparticles: A Green Approach to Combat Nanoparticle-Induced Oxidative Stress

Acharya Balkrishna | Ashwani Kumar | ... | Kamil Kuca
  • Special Issue
  • - Volume 2021
  • - Article ID 8511576
  • - Research Article

Anticancer, Enhanced Antibacterial, and Free Radical Scavenging Potential of Fucoidan- (Fucus vesiculosus Source) Mediated Silver Nanoparticles

S. Rajeshkumar | Eman F. Aboelfetoh | ... | Ramaswamy Krishnaraj
Oxidative Medicine and Cellular Longevity
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Acceptance rate33%
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CiteScore9.300
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Article of the Year Award: Outstanding research contributions of 2021, as selected by our Chief Editors. Read the winning articles.