Oxidative Medicine and Cellular Longevity

Interplay of Oxidative Stress, Inflammation, and Autophagy: Their Role in Tissue Injury of Heart, Liver, and Kidney


Publishing date
12 Jan 2018
Status
Published
Submission deadline
25 Aug 2017

1National Institutes of Health, Bethesda, USA

2Osaka Medical College, Takatsuki, Japan

3Uniformed Services University, Bethesda, USA


Interplay of Oxidative Stress, Inflammation, and Autophagy: Their Role in Tissue Injury of Heart, Liver, and Kidney

Description

Oxidative Medicine and Cellular Longevity invites manuscripts, whether a research article or review, from both scientists and clinicians to contribute their novel findings for this special issue. The disturbance of the balance of normal redox state of cells can cause toxic effects through the production of unchecked free radicals that target proteins, DNA, lipids, and vitamins, contributing to alterations of their normal functions, leading to the production of diverse biological effects and ultimately the development and/or progression of tissue injury. Oxidative stress may be developed and/or enhanced by various mechanisms. For instance, the development of inflammation and the alteration of autophagy are two major pathways that might play a critical role in the induction and/or progression of deleterious tissue injury via oxidative stress-mediated events.

Conversely, oxidative stress has been reported to mediate the development of inflammation as well as the alteration of autophagy. Thus, there might be either an independent role of each of these factors (i.e., oxidative stress, inflammation, and alteration of autophagy) or interplay among them to cause damaging effects on the tissues. Typically, a series of genes responds to injurious insults, leading to the activation of various pathways, ultimately dictating cell fate in either direction (i.e., whether cell survival or demise), depending on the level of unchecked cellular damage, and thus works as cell fate speedometer. The understanding of these molecular events that lead to these physiologic alterations may also serve as a valuable tool to broaden the perspective of targeted therapeutics which may enhance cellular longevity. These crucial events will be emphasized mainly in this issue for three major organs, namely, heart, liver, and kidney; however, other organs might be considered.

Potential topics include but are not limited to the following:

  • Expanding the existing knowledge and providing novel information regarding the role and mechanism(s) in response to endogenous or exogenous factors via which oxidative stress, inflammation, and alteration of autophagy mediate tissue injury, whether alone, combined, or via inducing and/or enhancing the harmful effects of each other in the heart, liver, and kidney
  • Providing novel models, methodologies, and treatments that might advance the fields involving these three major injurious factors

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 2090813
  • - Editorial

Interplay of Oxidative Stress, Inflammation, and Autophagy: Their Role in Tissue Injury of the Heart, Liver, and Kidney

Partha Mukhopadhyay | Nabil Eid | ... | Aditya Sen
  • Special Issue
  • - Volume 2018
  • - Article ID 3537609
  • - Research Article

A Novel Mechanism of Mesenchymal Stromal Cell-Mediated Protection against Sepsis: Restricting Inflammasome Activation in Macrophages by Increasing Mitophagy and Decreasing Mitochondrial ROS

Shuang Li | Hao Wu | ... | Feng Cao
  • Special Issue
  • - Volume 2018
  • - Article ID 9797146
  • - Research Article

Granulocyte Colony-Stimulating Factor Alleviates Bacterial-Induced Neuronal Apoptotic Damage in the Neonatal Rat Brain through Epigenetic Histone Modification

Yung-Ning Yang | Yu-Tsun Su | ... | San-Nan Yang
  • Special Issue
  • - Volume 2018
  • - Article ID 9389784
  • - Research Article

Cardiac Autonomic Neuropathy as a Result of Mild Hypercaloric Challenge in Absence of Signs of Diabetes: Modulation by Antidiabetic Drugs

Ola Al-Assi | Rana Ghali | ... | Ahmed F. El-Yazbi
  • Special Issue
  • - Volume 2018
  • - Article ID 6717212
  • - Research Article

Hydrogen Sulfide Attenuates LPS-Induced Acute Kidney Injury by Inhibiting Inflammation and Oxidative Stress

Yuhong Chen | Sheng Jin | ... | Yuming Wu
  • Special Issue
  • - Volume 2017
  • - Article ID 8024857
  • - Research Article

Exercise Combined with Rhodiola sacra Supplementation Improves Exercise Capacity and Ameliorates Exhaustive Exercise-Induced Muscle Damage through Enhancement of Mitochondrial Quality Control

Yaoshan Dun | Suixin Liu | ... | Ling Qiu
  • Special Issue
  • - Volume 2017
  • - Article ID 6109061
  • - Research Article

Immediate Early Response Gene X-1 (IEX-1) Mediates Ischemic Preconditioning-Induced Cardioprotection in Rats

Ming-Jiang Xu | Yan Cai | ... | Xian Wang
  • Special Issue
  • - Volume 2017
  • - Article ID 1401790
  • - Research Article

Baicalin Attenuates Subarachnoid Hemorrhagic Brain Injury by Modulating Blood-Brain Barrier Disruption, Inflammation, and Oxidative Damage in Mice

Xianqing Shi | Yongjian Fu | ... | Jin Chen
  • Special Issue
  • - Volume 2017
  • - Article ID 3140680
  • - Research Article

Ameliorative Effect of Daidzein on Cisplatin-Induced Nephrotoxicity in Mice via Modulation of Inflammation, Oxidative Stress, and Cell Death

Hongzhou Meng | Guanghou Fu | ... | Hao Pan
  • Special Issue
  • - Volume 2017
  • - Article ID 2302896
  • - Research Article

Apigenin Alleviates Endotoxin-Induced Myocardial Toxicity by Modulating Inflammation, Oxidative Stress, and Autophagy

Fang Li | Fangfang Lang | ... | Enkui Hao
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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