Oxidative Medicine and Cellular Longevity

Dietary Polyphenols and Their Effects on Cell Biochemistry and Pathophysiology 2014


Publishing date
13 Feb 2015
Status
Published
Submission deadline
26 Sep 2014

1University of Bologna, Bologna, Italy

2University of East Anglia, Norwich, UK

3University of Modena and Reggio Emilia, Modena, Italy

4INRA, Clermont-Ferrand, France


Dietary Polyphenols and Their Effects on Cell Biochemistry and Pathophysiology 2014

Description

Dietary polyphenols, along with other natural compounds occurring in fruit and vegetables, beverages such as wine and tea, extra virgin olive oil, chocolate, and other cocoa-derived products, have been reported to exert beneficial effects in a multitude of disease states, including cancer, cardiovascular disease, and neurodegenerative disorders. Historically, many of the biological actions of polyphenols have been attributed to their antioxidant properties, either through their reducing capacities per se or through their possible influences on intracellular redox status. However, during the last years, a new realisation of how nutritional antioxidants may function has been envisaged, and recent findings have suggested that, in complex biological systems and in lower amounts, typical of those attained in the diet, such molecules may exert several additional properties which are yet poorly understood.

As antioxidants, these natural compounds may protect cell constituents against oxidative damage, therefore limiting the risk of various oxidative stress-related degenerative diseases, such as cardiovascular diseases, type 2 diabetes, and cancer. However, accumulating evidence indicates that the classical hydrogen-donating antioxidant activity is unlikely to be the sole explanation for cellular effects of polyphenols and other natural compounds. It is evident that such dietary nutrients are potent bioactive molecules, and a clear understanding of their precise mechanisms of action as either antioxidants or modulators of cell signaling is crucial to the evaluation of their potential as anticancer agents and inhibitors of neurodegeneration.

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the precise effects of polyphenols and other natural compounds in vitro and in vivo. We are particularly interested in articles describing the molecular mechanisms of action by which these molecules exert their beneficial or toxic effects in degenerative diseases.

Potential topics include, but are not limited to:

  • Role of polyphenols and other natural compounds in molecular signalling
  • Role of polyphenols and other natural compounds in redox modulation
  • Effect of polyphenols and other natural compounds on apoptosis induction
  • Potential effect of polyphenols and other natural compounds on cancer
  • Potential effect of polyphenols and other natural compounds on neurodegenerative diseases
  • Potential effect of polyphenols and other natural compounds on cardiovascular diseases
  • Potential effect of polyphenols and other natural compounds on stem cell proliferation and differentiation

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 782424
  • - Editorial

Dietary Polyphenols and Their Effects on Cell Biochemistry and Pathophysiology 2014

Cristina Angeloni | Tullia Maraldi | ... | David Vauzour
  • Special Issue
  • - Volume 2015
  • - Article ID 740162
  • - Research Article

Carqueja (Baccharis trimera) Protects against Oxidative Stress and β-Amyloid-Induced Toxicity in Caenorhabditis elegans

Franciny Aparecida Paiva | Larissa de Freitas Bonomo | ... | Riva de Paula Oliveira
  • Special Issue
  • - Volume 2015
  • - Article ID 950890
  • - Review Article

Anticancer Properties of Phyllanthus emblica (Indian Gooseberry)

Tiejun Zhao | Qiang Sun | ... | Michael Witcher
  • Special Issue
  • - Volume 2015
  • - Article ID 781938
  • - Research Article

Neuroprotective Effect of Brassica oleracea Sprouts Crude Juice in a Cellular Model of Alzheimer’s Disease

Alessandra Masci | Roberto Mattioli | ... | Luciana Mosca
  • Special Issue
  • - Volume 2015
  • - Article ID 181260
  • - Review Article

Molecular Mechanisms and Therapeutic Effects of (−)-Epicatechin and Other Polyphenols in Cancer, Inflammation, Diabetes, and Neurodegeneration

Joseph Shay | Hosam A. Elbaz | ... | Maik Hüttemann
  • Special Issue
  • - Volume 2015
  • - Article ID 403023
  • - Research Article

Antioxidative Effects and Inhibition of Human Low Density Lipoprotein Oxidation In Vitro of Polyphenolic Compounds in Flammulina velutipes (Golden Needle Mushroom)

Mohammad Azizur Rahman | Noorlidah Abdullah | Norhaniza Aminudin
  • Special Issue
  • - Volume 2015
  • - Article ID 854015
  • - Review Article

Interactions between CYP3A4 and Dietary Polyphenols

Loai Basheer | Zohar Kerem
  • Special Issue
  • - Volume 2015
  • - Article ID 673847
  • - Research Article

Polymethoxyflavone Apigenin-Trimethylether Suppresses LPS-Induced Inflammatory Response in Nontransformed Porcine Intestinal Cell Line IPEC-J2

Orsolya Farkas | Orsolya Palócz | ... | Péter Gálfi
  • Special Issue
  • - Volume 2015
  • - Article ID 504253
  • - Review Article

Role of Polyphenols and Other Phytochemicals on Molecular Signaling

Swapna Upadhyay | Madhulika Dixit
  • Special Issue
  • - Volume 2015
  • - Article ID 351827
  • - Research Article

Protocatechuic Acid Prevents oxLDL-Induced Apoptosis by Activating JNK/Nrf2 Survival Signals in Macrophages

Rosaria Varì | Beatrice Scazzocchio | ... | Claudio Giovannini
Oxidative Medicine and Cellular Longevity
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Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.900
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