Oxidative Medicine and Cellular Longevity

Dietary Polyphenols and Their Effects on Cell Biochemistry and Pathophysiology 2014


Publishing date
13 Feb 2015
Status
Published
Submission deadline
26 Sep 2014

1University of Bologna, Bologna, Italy

2University of East Anglia, Norwich, UK

3University of Modena and Reggio Emilia, Modena, Italy

4INRA, Clermont-Ferrand, France


Dietary Polyphenols and Their Effects on Cell Biochemistry and Pathophysiology 2014

Description

Dietary polyphenols, along with other natural compounds occurring in fruit and vegetables, beverages such as wine and tea, extra virgin olive oil, chocolate, and other cocoa-derived products, have been reported to exert beneficial effects in a multitude of disease states, including cancer, cardiovascular disease, and neurodegenerative disorders. Historically, many of the biological actions of polyphenols have been attributed to their antioxidant properties, either through their reducing capacities per se or through their possible influences on intracellular redox status. However, during the last years, a new realisation of how nutritional antioxidants may function has been envisaged, and recent findings have suggested that, in complex biological systems and in lower amounts, typical of those attained in the diet, such molecules may exert several additional properties which are yet poorly understood.

As antioxidants, these natural compounds may protect cell constituents against oxidative damage, therefore limiting the risk of various oxidative stress-related degenerative diseases, such as cardiovascular diseases, type 2 diabetes, and cancer. However, accumulating evidence indicates that the classical hydrogen-donating antioxidant activity is unlikely to be the sole explanation for cellular effects of polyphenols and other natural compounds. It is evident that such dietary nutrients are potent bioactive molecules, and a clear understanding of their precise mechanisms of action as either antioxidants or modulators of cell signaling is crucial to the evaluation of their potential as anticancer agents and inhibitors of neurodegeneration.

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the precise effects of polyphenols and other natural compounds in vitro and in vivo. We are particularly interested in articles describing the molecular mechanisms of action by which these molecules exert their beneficial or toxic effects in degenerative diseases.

Potential topics include, but are not limited to:

  • Role of polyphenols and other natural compounds in molecular signalling
  • Role of polyphenols and other natural compounds in redox modulation
  • Effect of polyphenols and other natural compounds on apoptosis induction
  • Potential effect of polyphenols and other natural compounds on cancer
  • Potential effect of polyphenols and other natural compounds on neurodegenerative diseases
  • Potential effect of polyphenols and other natural compounds on cardiovascular diseases
  • Potential effect of polyphenols and other natural compounds on stem cell proliferation and differentiation

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 894597
  • - Research Article

Protective Pleiotropic Effect of Flavonoids on NAD+ Levels in Endothelial Cells Exposed to High Glucose

Daniëlle M. P. H. J. Boesten | Saskia N. I. von Ungern-Sternberg | ... | Aalt Bast
  • Special Issue
  • - Volume 2015
  • - Article ID 248529
  • - Review Article

Psychiatric Disorders and Polyphenols: Can They Be Helpful in Therapy?

Jana Trebatická | Zdeňka Ďuračková
  • Special Issue
  • - Volume 2015
  • - Article ID 721514
  • - Review Article

Age-Related Cognitive Impairment as a Sign of Geriatric Neurocardiovascular Interactions: May Polyphenols Play a Protective Role?

Fedor Jagla | Olga Pechanova
  • Special Issue
  • - Volume 2015
  • - Article ID 154164
  • - Research Article

Impact of Procyanidins from Different Berries on Caspase 8 Activation in Colon Cancer

Carole Minker | Livine Duban | ... | Christian D. Muller
  • Special Issue
  • - Volume 2015
  • - Article ID 340520
  • - Review Article

Polyphenol Stilbenes: Molecular Mechanisms of Defence against Oxidative Stress and Aging-Related Diseases

Mika Reinisalo | Anna Kårlund | ... | Reijo O. Karjalainen
  • Special Issue
  • - Volume 2015
  • - Article ID 463797
  • - Review Article

Development of Antiatherosclerotic Drugs on the basis of Natural Products Using Cell Model Approach

Alexander N. Orekhov | Igor A. Sobenin | ... | Yuri V. Bobryshev
  • Special Issue
  • - Volume 2014
  • - Article ID 639868
  • - Research Article

Effect of the French Oak Wood Extract Robuvit on Markers of Oxidative Stress and Activity of Antioxidant Enzymes in Healthy Volunteers: A Pilot Study

Martina Horvathova | Zuzana Orszaghova | ... | Jana Muchova
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.900
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