Oxidative Medicine and Cellular Longevity

Heme Oxygenase-1 as a Novel Metabolic Player

Publishing date
06 Dec 2013
Submission deadline
19 Jul 2013

Lead Editor

1School of Biological Sciences, Ulsan University, Ulsan 680-749, Republic of Korea

2The Pulmonary and Critical Care Medicine (PCCM) Division, Brigham and Women's Hospital (BWH), Harvard Medical School, Boston, MA 02115, USA

3School of Pharmacy, Ajou University, Suwon 443-749, Republic of Korea

Heme Oxygenase-1 as a Novel Metabolic Player


Heme is not only an oxygen transporter or reservoir as in hemoglobin or myoglobin but also has many other functions, such as electron transport in the respiratory chain, oxygen sensing, and metabolism. However, free heme is toxic; organisms develop to evade from its toxicity through degrading heme into nontoxic metabolites. Indeed, heme oxygenase (HO) or heme oxygenase-like enzymes are found in bacteria, plants, and mammalians as well. At least 3 isoforms of HO enzyme are discovered. HO-1 is an inducible form of enzyme in response to various stressful conditions. It has been demonstrated that HO-1 activity reduces inflammation and inhibits cellular proliferation and apoptosis, thus rendering cytoprotective potential. Its metabolites produced by enzymatic activity, bilirubin, and carbon monoxide (CO) are in some degree responsible for the biological activity of HO-1.

More recent evidence has underscored the novel role of the HO/CO system in metabolic diseases including diabetes. Elevated oxidative stress plays a key role in insulin insensitivity and glucose intolerance; attenuating the stress by HO-1 may slow the progression of diabetes and obesity-related syndromes. In concert with this, HO-1 activity upregulates adiponectin levels and enhances glucose metabolism. We invite investigators to contribute original research articles as well as review articles to this special issue. Potential topics include, but are not limited to

  • Contribution of HO-1/CO system for the suppression of metabolic diseases
  • Modulation of metabolic diseases by nutraceuticals augmenting HO-1 activity
  • Mitochondrial biogenesis and metabolic disorder: role of HO-1
  • Crosstalk between biologically active gases in metabolic diseases: nitric oxide, carbon monoxide, and hydrogen sulfide
  • HO-1-mediated autophagy regulates oxidative stresses in metabolic disorders
  • A novel pathway to get energy in cancer cells: HO-1 and tumor metabolism

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/oximed/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/author/submit/journals/oximed/honm/ according to the following timetable:

Oxidative Medicine and Cellular Longevity
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