As essential components of the cell membrane and secondary messenger molecules, lipids play crucial roles in maintaining cellular and tissue homeostasis. Disruption of lipid metabolism has been implicated in the onset and progression of various human diseases, ranging from metabolic disorders, cardiovascular disease, as well as neurodegenerative disease, to viral and bacterial infections. Therefore, it is paramount to better understand the process and precise regulation of lipid metabolism in health and disease.

Lipid peroxidation is one of the commonly occurring events of lipid dysregulation in the body. Lipid peroxidation is the chain of reactions of oxidative degradation, where the free radicals generated can further act as signaling molecules or react with other biomolecules in the cell, resulting in pathophysiological processes, such as oxidative stress, inflammation, and cell death. The oxidation products over-produced by lipid peroxidation accumulate in cells and can lead to organelle dysfunction, especially endoplasmic reticulum, mitochondria, lysosome, and peroxisome dysfunction. Consequentially, more free radicals such as reactive oxygen species (ROS) will be produced which exacerbate oxidative damage and expedite the disease progression.

The purpose of this Special Issue is to encourage researchers to submit original research and review articles which address all aspects of lipid metabolism and the mechanisms linking lipid peroxidation and oxidative stress, inflammation, and cell death in human diseases or using preclinical animal models. This Special Issue aims to attract research which will translate this knowledge into new treatments and therapeutic strategies. Studies discussing the interaction between host lipid peroxidation and microorganisms including bacteria and viruses are also welcome. In addition, new methods to track the transportation of specific lipids in cell organelles are of interest.

Potential topics include but are not limited to the following:

• Lipid peroxidation in metabolic disorders and chronic diseases
• Mechanisms of lipid peroxidation-induced oxidative stress, inflammation, and cell death
• Mechanisms by which lipid peroxidation affects organelle function
• Host-bacteria/viruses interaction: the role of host-specific lipid peroxidation in infection
• Novel methods/tools to study the transportation of specific lipids in cell organelles