Oxidative Medicine and Cellular Longevity

Redox Imbalance and Stroke


Status
Published

Lead Editor

1Nanjing University, Nanjing, China

2Xijing Hospital, Xi’an, China

3Cardiff University, Cardiff, UK

4Henry Ford Hospital, Detroit, USA


Redox Imbalance and Stroke

Description

Stroke includes cerebral infarction (ischemic stroke), intracerebral hemorrhage, and subarachnoid hemorrhage. According to the World Health Organization, annually 15 million people suffer first-ever stroke worldwide, causing a total of 5.7 million deaths. Redox imbalance is a hallmark event in the pathogenesis, pathophysiology, and prognosis of stroke. Excessive reactive oxygen species (ROS) can cause oxidative damage to various biological macromolecules including DNA, lipids, and proteins, thereby altering several signaling pathways that ultimately promote cellular damage and death. Recently, it has become increasingly clear that ROS at physiological levels are important signaling molecules maintaining cell homeostasis. Redox status is correlated with mitochondrial function, lipid raft turnover, and cross-talk between cells in neurovascular coupling. Transient ROS elevation promotes prosurvival signaling and functions as putative essential trigger in preconditioning-induced neuroprotection.

Thus, it is critical to address the relationship between redox status and stroke and to translate the accumulated mechanistic knowledge from animal models to clinical settings. We invite investigators to contribute original researches in animal models or humans and review articles that drive a better understanding of how redox imbalance modulates signaling pathways and how this can be harnessed as a therapeutic target in the stroke treatment.

Potential topics include, but are not limited to:

  • Role of redox imbalance in the pathophysiology of stroke
  • Role of redox imbalance and inflammation in the progression of cerebral atherosclerosis
  • The relationship of hemodynamics and endothelial redox imbalance
  • Role of redox imbalance in the cross-talk between cells in neurovascular coupling
  • Role of redox stress in the preconditioning and postconditioning
  • Therapies targeting redox imbalance for stroke in animal models or patients
  • Clinical redox status and oxidative stress-based biomarkers predicting the outcomes after stroke
  • Clinical trials and mechanism investigations of approved drugs with antioxidative properties in stroke prevention and treatment

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 3065263
  • - Editorial

Redox Imbalance and Stroke

Ruidong Ye | Ming Shi | ... | Jieli Chen
  • Special Issue
  • - Volume 2016
  • - Article ID 1843201
  • - Research Article

Tissue Kallikrein Alleviates Cerebral Ischemia-Reperfusion Injury by Activating the B2R-ERK1/2-CREB-Bcl-2 Signaling Pathway in Diabetic Rats

Ruifeng Shi | Kunxiong Yuan | ... | Renliang Zhang
  • Special Issue
  • - Volume 2016
  • - Article ID 6906712
  • - Review Article

The Role of Omega-3 Polyunsaturated Fatty Acids in Stroke

Jiyuan Bu | Yang Dou | ... | Gang Chen
  • Special Issue
  • - Volume 2016
  • - Article ID 1341453
  • - Research Article

Chronic Alcohol Intoxication and Cortical Ischemia: Study of Their Comorbidity and the Protective Effects of Minocycline

Enéas Andrade Fontes-Júnior | Cristiane Socorro Ferraz Maia | ... | Maria Elena Crespo-López
  • Special Issue
  • - Volume 2016
  • - Article ID 2592935
  • - Review Article

The Injury and Therapy of Reactive Oxygen Species in Intracerebral Hemorrhage Looking at Mitochondria

Jie Qu | Weixiang Chen | ... | Hua Feng
  • Special Issue
  • - Volume 2016
  • - Article ID 8346301
  • - Research Article

Metabolic Syndrome Augments the Risk of Early Neurological Deterioration in Acute Ischemic Stroke Patients Independent of Inflammatory Mediators: A Hospital-Based Prospective Study

Xiaohao Zhang | Zhiguang Sun | ... | Lei Sheng
  • Special Issue
  • - Volume 2016
  • - Article ID 9026787
  • - Research Article

Lower Serum Caveolin-1 Is Associated with Cerebral Microbleeds in Patients with Acute Ischemic Stroke

Jun Zhang | Wusheng Zhu | ... | Gelin Xu
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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