Oxidative Medicine and Cellular Longevity

Oxidants and Redox Signaling: Perspectives in Cancer Therapy, Inflammation, and Plasma Medicine


Status
Published

1Leibniz-Institute for Plasma Science and Technology, Greifswald, Germany

2Karolinska Institutet, Stockholm, Sweden

3Heinrich-Heine Universität Düsseldorf, Düsseldorf, Germany


Oxidants and Redox Signaling: Perspectives in Cancer Therapy, Inflammation, and Plasma Medicine

Description

Redox signaling is a key player in the regulation of physiological processes. Current concepts in redox biology and plasma medicine emphasize the significance of redox dysregulation in inflammation and different pathologies including cancer. The identification and characterization of specific protein thiol switches and redox regulated signaling pathways are one of the challenges in the fields. Tumor cells are often localized in a hypoxic environment which leads to a unique redox signaling environment affecting metabolism, proliferation, metastasis, apoptosis, and angiogenesis and the immune response. Deciphering and understanding the specific redox regulation of particular molecules and processes in a physiological and pathological context could allow the development of new therapeutic avenues. These strategies could comprise the therapeutic application of small molecules specifically targeting thiol switches and dysregulated redox signaling cascades, or, for example, cold physical plasma sources (such as plasma jets) which are able to generate reactive oxygen species in a spatially restricted manner without thermal damage to surrounding tissue.

We invite investigators to contribute original research articles as well as review articles that seek to address the mechanisms and significance of oxidant-induced redox signaling events in cancer, immunology, and inflammation. A particular interest will be given to papers exploring or discussing new concepts in cancer therapy using exogenously generated ROS/RNS via cold physical plasma sources with an emphasis on deepening the understanding of plasma-cell interactions.

Potential topics include but are not limited to the following:

  • Redox homeostasis and protein thiol switches/ biochemical studies on redox reactions, redox regulated signaling cascades, and their cellular impact
  • Metastatic potential and apoptosis of cancer cells
  • Modulation of tumor microenvironment
  • Cross-talk between cancer and immune cells
  • Cold physical plasma sources for tumor therapy or for directing inflammation
  • Mechanistic investigations on physical plasma derived oxidant and radical formation

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 4020253
  • - Editorial

Oxidants and Redox Signaling: Perspectives in Cancer Therapy, Inflammation, and Plasma Medicine

Sander Bekeschus | Lars Bräutigam | ... | Eva-Maria Hanschmann
  • Special Issue
  • - Volume 2017
  • - Article ID 8459402
  • - Review Article

Redox Regulation of Inflammatory Processes Is Enzymatically Controlled

Inken Lorenzen | Lisa Mullen | ... | Eva-Maria Hanschmann
  • Special Issue
  • - Volume 2017
  • - Article ID 7395238
  • - Research Article

The Synthetic Lignan Secoisolariciresinol Diglucoside Prevents Asbestos-Induced NLRP3 Inflammasome Activation in Murine Macrophages

Ralph A. Pietrofesa | Patrick Woodruff | ... | Melpo Christofidou-Solomidou
  • Special Issue
  • - Volume 2017
  • - Article ID 4271065
  • - Research Article

Cold Atmospheric Plasma Induces Apoptosis and Oxidative Stress Pathway Regulation in T-Lymphoblastoid Leukemia Cells

Eleonora Turrini | Romolo Laurita | ... | Carmela Fimognari
  • Special Issue
  • - Volume 2017
  • - Article ID 2487297
  • - Research Article

2-Deoxy-D-glucose Restore Glucocorticoid Sensitivity in Acute Lymphoblastic Leukemia via Modification of N-Linked Glycosylation in an Oxygen Tension-Independent Manner

Zaira Leni | Paulina Ćwiek | ... | Alexandre Arcaro
  • Special Issue
  • - Volume 2017
  • - Article ID 2597581
  • - Review Article

Oxidative Stress Gene Expression Profile Correlates with Cancer Patient Poor Prognosis: Identification of Crucial Pathways Might Select Novel Therapeutic Approaches

Alessandra Leone | Maria Serena Roca | ... | Alfredo Budillon
  • Special Issue
  • - Volume 2017
  • - Article ID 4396467
  • - Research Article

Toxicity and Immunogenicity in Murine Melanoma following Exposure to Physical Plasma-Derived Oxidants

Sander Bekeschus | Katrin Rödder | ... | Rajesh Kumar Gandhirajan
  • Special Issue
  • - Volume 2016
  • - Article ID 9460462
  • - Research Article

The Protective Roles of ROS-Mediated Mitophagy on 125I Seeds Radiation Induced Cell Death in HCT116 Cells

Lelin Hu | Hao Wang | ... | Junjie Wang
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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