Oxidative Medicine and Cellular Longevity

Natural Bioactive Compounds Acting Against Oxidative Stress in Chronic, Degenerative, and Infectious Diseases


Publishing date
01 Aug 2018
Status
Published
Submission deadline
13 Apr 2018

1Sapienza University of Rome, Rome, Italy

2Universidad de La Habana, Habana, Cuba

3Temple University School of Medicine, Philadelphia, USA

4RWTH Aachen University, Aachen, Germany


Natural Bioactive Compounds Acting Against Oxidative Stress in Chronic, Degenerative, and Infectious Diseases

Description

Despite continued efforts towards primary prevention, many chronic and degenerative diseases such as cancer, neurodegenerative disorders, and metabolic diseases are yet the most common causes of death and disability in industrialized countries. Common denominator of these diseases is oxidative stress which in turn may elicit chronic inflammation. Natural bioactive compounds from vegetables, including polyphenols, flavonoids, and anthocyanins but also micronutrient and vitamins, are well known for their antioxidant and anti-inflammatory role and have been proposed as possible therapeutic agents against these diseases.

Indeed, many epidemiological studies suggest that a large consumption of vegetables can counteract the development of several chronic, degenerative, and infectious disorders. These protective effects have been attributed to the high polyphenolic content in several plants and in general to their high amount of bioactive compounds. In addition to epidemiological studies, a number of in vitro experimental studies have shown the antioxidant and protective capacity of single purified bioactive molecules against several diseases, exerted by the modulation of the cellular redox balance and via interaction with cellular functions at different levels. However, it must be emphasized that the bioavailability and solubility within the organism of single isolated bioactive molecules as well as the alterations that these molecules undergo during metabolic processes could decrease their efficacy in vivo. An alternative and equally promising approach is the use of complex mixtures of bioactive molecules that appear to be very effective both in vitro and in vivo, possibly because of the synergistic action among different polyphenols and/or other food components such as vitamins and minerals. Although only a few studies have investigated the potential protective effect of complex mixtures of bioactive compounds, there is a growing interest in the study of the interactions between different phytochemicals contained in foods and how these affect cellular molecular processes and/or gene expression.

In this special issue, we invite investigators to contribute with original research articles, as well as review articles, which provide a better understanding of the effects of single and/or complex mixtures of natural bioactive molecules on chronic, degenerative, and infectious diseases.

Potential topics include but are not limited to the following:

  • Antioxidant activity of natural compounds
  • Polyphenols, flavonoids, and anthocyanins against neurodegenerative disorders
  • Natural bioactive compounds in cancer prevention and treatment
  • Glucosinolates and their protection against degenerative disorders
  • Natural bioactive compounds in metabolic disorders
  • Plant miRNA and its novel therapeutic uses
  • Effects of sulfur containing compounds on arthritis, diabetes, and cancer
  • Bacterial and yeast antimicrobial peptides

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 3894381
  • - Editorial

Natural Bioactive Compounds Acting against Oxidative Stress in Chronic, Degenerative, and Infectious Diseases

Roberto Mattioli | Luciana Mosca | ... | Ralf Hausmann
  • Special Issue
  • - Volume 2018
  • - Article ID 7560610
  • - Research Article

Palmitate Stimulates the Epithelial Sodium Channel by Elevating Intracellular Calcium, Reactive Oxygen Species, and Phosphoinositide 3-Kinase Activity

Qiu-Shi Wang | Chen Liang | ... | He-Ping Ma
  • Special Issue
  • - Volume 2018
  • - Article ID 7019573
  • - Research Article

Treatment of NASH with Antioxidant Therapy: Beneficial Effect of Red Cabbage on Type 2 Diabetic Rats

Stéphanie Dal | Remmelt Van der Werf | ... | Séverine Sigrist
  • Special Issue
  • - Volume 2018
  • - Article ID 5082817
  • - Research Article

Evodiamine Attenuates P2X7-Mediated Inflammatory Injury of Human Umbilical Vein Endothelial Cells Exposed to High Free Fatty Acids

Yun Xue | Ting Guo | ... | Guodong Li
  • Special Issue
  • - Volume 2018
  • - Article ID 9354296
  • - Research Article

In Vivo Evaluation of the Antioxidant Activity and Protective Action of the Seaweed Gracilaria birdiae

Joanna Angelis Costa Barros-Gomes | Daiany Laise Araújo Nascimento | ... | Hugo Alexandre Oliveira Rocha
  • Special Issue
  • - Volume 2018
  • - Article ID 1826170
  • - Review Article

Anticancer Properties of Graviola (Annona muricata): A Comprehensive Mechanistic Review

Islam Rady | Melissa B. Bloch | ... | Jean Christopher Chamcheu
  • Special Issue
  • - Volume 2018
  • - Article ID 5919237
  • - Research Article

Antiviral and Antioxidant Activity of a Hydroalcoholic Extract from Humulus lupulus L.

Antonella Di Sotto | Paola Checconi | ... | Lucia Nencioni
  • Special Issue
  • - Volume 2018
  • - Article ID 8597897
  • - Research Article

Salidroside Attenuates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease via AMPK-Dependent TXNIP/NLRP3 Pathway

Tao Zheng | Xiaoyan Yang | ... | Si Jin
  • Special Issue
  • - Volume 2018
  • - Article ID 9241308
  • - Research Article

Guarana (Paullinia cupana) Extract Protects Caenorhabditis elegans Models for Alzheimer Disease and Huntington Disease through Activation of Antioxidant and Protein Degradation Pathways

Patrícia Ferreira Boasquívis | Giovanna Melo Martins Silva | ... | Riva de Paula Oliveira
  • Special Issue
  • - Volume 2018
  • - Article ID 2876350
  • - Research Article

Activating the PGC-1α/TERT Pathway by Catalpol Ameliorates Atherosclerosis via Modulating ROS Production, DNA Damage, and Telomere Function: Implications on Mitochondria and Telomere Link

Yukun Zhang | Changyuan Wang | ... | Huijun Sun
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision74 days
Acceptance to publication36 days
CiteScore4.520
Impact Factor4.868
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