Oxidative Medicine and Cellular Longevity

Discovery and Biological Evaluation of Natural Phenolic Antioxidants


Status
Published

Lead Editor

1University of California at San Diego, San Diego, USA

2The City College of New York, New York, USA

3Chengdu Institute of Biology, Chengdu, China

4Macau University of Science and Technology, Macau, China


Discovery and Biological Evaluation of Natural Phenolic Antioxidants

Description

Historically, natural products have played an important role in drug discovery to combat a variety of diseases. Today natural products remain an important source of drugs and drug leads despite the development of high throughput screening of combinatorial libraries during the past two decades. Recently, as oxidative stress has been increasingly recognized as a significant contributing factor in the pathogenesis of various disorders, numerous studies have been performed to explore the positive role of natural antioxidants in the prevention and treatment of oxidative stress-related diseases, such as pulmonary disorders, neurodegeneration, cardiovascular diseases, and cancer. Oxidative stress results from the imbalance between reactive oxygen or nitrogen species (ROS or RNS) and antioxidants. Phenolic natural compounds such as flavonoids, anthocyanins, stilbenes, tanins, and phenolic acids are well known antioxidants that scavenge and therefore potentially protect against ROS- or RNS-induced in vivo damage. However, a large number of phenolic natural products remain unexplored with respect to their antioxidant properties. Furthermore, substantial evidence is needed to elucidate the molecular mechanisms of different classes of phenolic compounds involved in the potential protective effects against oxidative stress.

The objective of this special issue is to highlight the discovery as well as biochemical and pharmacological evaluation of natural phenolic antioxidants. We cordially invite investigators to contribute original research articles, comprehensive reviews, and perspective articles aiming to provide insights into the identification, evaluation, and quality control of phenolic antioxidants and to ultimately form solid scientific basis for the usage of these chemical constituents to prevent and treat oxidative stress-related diseases.

Potential topics include but are not limited to the following:

  • Bioactivity guided isolation and identification of new phenolic compounds from natural sources demonstrating in vivo antioxidant activity
  • Quality control of phenolic antioxidants and validation of antioxidant assays
  • Elucidation of the molecular mechanisms behind antioxidant activities of phenolic natural products
  • Pharmacokinetic profiling and bioavailability studies on phenolic compounds

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 2649129
  • - Editorial

Discovery and Biological Evaluation of Natural Phenolic Antioxidants

Jie Li | Keyvan Dastmalchi | ... | Pei Luo
  • Special Issue
  • - Volume 2017
  • - Article ID 4175353
  • - Research Article

Resveratrol Ameliorates Mitochondrial Elongation via Drp1/Parkin/PINK1 Signaling in Senescent-Like Cardiomyocytes

Xuecong Ren | Li Chen | ... | Pei Luo
  • Special Issue
  • - Volume 2017
  • - Article ID 1891849
  • - Research Article

Carlina vulgaris L. as a Source of Phytochemicals with Antioxidant Activity

Maciej Strzemski | Magdalena Wójciak-Kosior | ... | Sławomir Dresler
  • Special Issue
  • - Volume 2017
  • - Article ID 1480294
  • - Research Article

Ginger Oleoresin Alleviated γ-Ray Irradiation-Induced Reactive Oxygen Species via the Nrf2 Protective Response in Human Mesenchymal Stem Cells

Kaihua Ji | Lianying Fang | ... | Qiang Liu
  • Special Issue
  • - Volume 2017
  • - Article ID 1459497
  • - Review Article

The Beneficial Effects of Quercetin, Curcumin, and Resveratrol in Obesity

Yueshui Zhao | Bo Chen | ... | Zhangang Xiao
  • Special Issue
  • - Volume 2017
  • - Article ID 8273160
  • - Research Article

Enhancement of Antioxidant Mechanisms and Reduction of Oxidative Stress in Chickens after the Administration of Drinking Water Enriched with Polyphenolic Powder from Olive Mill Waste Waters

Aliki Papadopoulou | Konstantinos Petrotos | ... | Demetrios Kouretas
  • Special Issue
  • - Volume 2017
  • - Article ID 4130967
  • - Research Article

Seabuckthorn Paste Protects Lipopolysaccharide-Induced Acute Lung Injury in Mice through Attenuation of Oxidative Stress

Leilei Du | Xiaoxin Hu | ... | Li Wan
  • Special Issue
  • - Volume 2017
  • - Article ID 7091904
  • - Research Article

Rosmarinic Acid Alleviates the Endothelial Dysfunction Induced by Hydrogen Peroxide in Rat Aortic Rings via Activation of AMPK

Hui Zhou | Baocai Fu | ... | Zhenhua Wang
  • Special Issue
  • - Volume 2017
  • - Article ID 8192383
  • - Review Article

Salvianolic Acid Exerts Cardioprotection through Promoting Angiogenesis in Animal Models of Acute Myocardial Infarction: Preclinical Evidence

Long-jie Yu | Ke-Jian Zhang | ... | Mao-Ping Chu
  • Special Issue
  • - Volume 2017
  • - Article ID 3631565
  • - Research Article

Hepatoprotective Effect of Polyphenol-Enriched Fraction from Folium Microcos on Oxidative Stress and Apoptosis in Acetaminophen-Induced Liver Injury in Mice

Hongtan Wu | Gang Zhang | ... | Gueyhorng Wang
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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