Oxidative Medicine and Cellular Longevity

Mitochondrial Structure, Function, and Dynamics: The Common Thread across Organs, Disease, and Aging


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Published

Lead Editor

1Wayne State University, Detroit, USA

2Dankook University, Yongin-si, Republic of Korea


Mitochondrial Structure, Function, and Dynamics: The Common Thread across Organs, Disease, and Aging

Description

Mitochondria are central to all basic and advanced cellular and organismal functions. In addition to the vast majority of cellular energy generated by these unique organelles, they are also essential signaling hubs and communicate with the rest of the cell through various means including reactive oxygen species. Their dysfunction is implicated in essentially all common diseases ranging from neuromuscular disease to diabetes and cancer.

The aim of this special issue is to provide the readership with current examples of how mitochondria function and how different adverse conditions result in their dysfunction. Therefore, we invite scientists to contribute original research as well as review articles ranging from basic science to clinical studies. Moreover, we welcome studies that focus on the role of mitochondria in various organs such as, but not limited to, the brain, heart, liver, kidney, reproductive organs, and muscle.

Potential topics include but are not limited to the following:

  • Role of inflammation on mitochondrial structure, function, and/or dynamics
  • Role of aging on mitochondria structure, function, and/or dynamics
  • Role of environmental pollutants/toxins on mitochondrial structure, function, and/or dynamics
  • Regulation of energy metabolism and the production of reactive oxygen species
  • Tissue-specific mitochondrial dysfunction across various organs
  • Countermeasures to mitochondrial dysfunction resulting from a disease
  • Apoptosis

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 3064016
  • - Research Article

Increased Mitochondrial Mass and Cytosolic Redox Imbalance in Hippocampal Astrocytes of a Mouse Model of Rett Syndrome: Subcellular Changes Revealed by Ratiometric Imaging of JC-1 and roGFP1 Fluorescence

Dörthe F. Bebensee | Karolina Can | Michael Müller
  • Special Issue
  • - Volume 2017
  • - Article ID 7038603
  • - Research Article

Pleiotropic Effects of Biguanides on Mitochondrial Reactive Oxygen Species Production

Alena Pecinova | Zdenek Drahota | ... | Tomas Mracek
  • Special Issue
  • - Volume 2017
  • - Article ID 7054272
  • - Research Article

Elucidation of Molecular Mechanisms of Streptozotocin-Induced Oxidative Stress, Apoptosis, and Mitochondrial Dysfunction in Rin-5F Pancreatic β-Cells

Arwa M. T. Al Nahdi | Annie John | Haider Raza
  • Special Issue
  • - Volume 2017
  • - Article ID 7202589
  • - Research Article

Combined Respiratory Chain Deficiency and UQCC2 Mutations in Neonatal Encephalomyopathy: Defective Supercomplex Assembly in Complex III Deficiencies

René G. Feichtinger | Michaela Brunner-Krainz | ... | Johannes A. Mayr
  • Special Issue
  • - Volume 2017
  • - Article ID 3292087
  • - Review Article

Disrupted Skeletal Muscle Mitochondrial Dynamics, Mitophagy, and Biogenesis during Cancer Cachexia: A Role for Inflammation

Brandon N. VanderVeen | Dennis K. Fix | James A. Carson
  • Special Issue
  • - Volume 2017
  • - Article ID 1372640
  • - Research Article

Mitochondrial Respiration in Human Colorectal and Breast Cancer Clinical Material Is Regulated Differently

Andre Koit | Igor Shevchuk | ... | Tuuli Kaambre
  • Special Issue
  • - Volume 2017
  • - Article ID 6408278
  • - Research Article

Mitochondria-Targeted Antioxidant SkQ1 Improves Dermal Wound Healing in Genetically Diabetic Mice

Ilya A. Demyanenko | Vlada V. Zakharova | ... | Ekaterina N. Popova
  • Special Issue
  • - Volume 2017
  • - Article ID 1320241
  • - Research Article

Oxidative Phosphorylation System in Gastric Carcinomas and Gastritis

René G. Feichtinger | Daniel Neureiter | ... | Barbara Kofler
  • Special Issue
  • - Volume 2017
  • - Article ID 6739236
  • - Review Article

MNRR1, a Biorganellar Regulator of Mitochondria

Lawrence I. Grossman | Neeraja Purandare | ... | Siddhesh Aras
  • Special Issue
  • - Volume 2017
  • - Article ID 8060949
  • - Review Article

Mitochondrial Nucleoid: Shield and Switch of the Mitochondrial Genome

Sung Ryul Lee | Jin Han
Oxidative Medicine and Cellular Longevity
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