Oxidative Medicine and Cellular Longevity

Oxidative Stress and Inflammation in Hepatic Diseases: Current and Future Therapy


Status
Published

Guest Editors

1George Washington University, Washington, USA

2Cinvestav, Mexico City, Mexico

3The George Washington University, Washington, USA


Oxidative Stress and Inflammation in Hepatic Diseases: Current and Future Therapy

Description

Liver disease is highly prevalent in the world. The continuous exposure of the liver to some factors, such as viruses, alcohol, fat, and biotransformed metabolites, among others, can cause hepatic injury, which can lead to inflammation and liver degeneration. When the injury is sustained for a long time, it can cause chronic liver diseases (CLDs), which include a spectrum of disease states ranging from simple steatosis and steatohepatitis (steatosis with inflammation and hepatocyte injury and death) to fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Although the clinical manifestations of liver disease are well-described, the mechanisms underlying development of this disease and its progression from steatosis alone to hepatocellular injury to chronic liver disease remain poorly understood. Multiple evidences indicate that oxidative stress and inflammation are the most important pathogenetic events in liver diseases, regardless of the different etiology and natural course. Most if not all the pathogenic insults in the liver can cause oxidative stress, inducing reactive oxygen species (ROS) generation, protein oxidation, and DNA damage. Further, CLDs lead to macrophage overactivation from inflammatory stimuli and increased release of proinflammatory and profibrogenic mediators that contribute to the hepatocyte necrosis and apoptosis. In addition, Kupffer cells (KC) induce activation of the immune system, innate and adaptive, with polymorphonuclear (PMN) leukocytes infiltration, inducible nitric oxide synthase (iNOS) upregulation, and recruitment of lymphocytes through the portal tract, hepatic vein, and sinusoids. In chronic liver diseases, hepatocyte injury triggers hepatic stellate cell (HSC), the major cell type responsible for the progression of liver fibrosis. Following liver injury, multiple physiological processes are altered in HSC including loss of their vitamin A stores, increased cytoskeleton contractility, and the expression of fibrogenic genes. These alterations in HSC are collectively known as HSC “transdifferentiation.” Together, these changes are the cause for the formation of scar tissue observed in fibrotic and cirrhotic livers.

Current therapies in chronic liver diseases are limited and liver transplantation is the only available treatment for end-stage liver disease. Therefore, there is a vital need for novel approaches and therapeutically aligned basic, clinical, and translational research as hepatic damage-related morbidity and mortality continue to exert a substantial toll on the world. Our aim is to bring together novel research and insight views on the role of oxidative stress and inflammation during hepatic diseases. We invite authors to contribute original research articles and review articles that will illustrate and stimulate the fundamental mechanisms as well as clinical treatments for CLDs. Only through a better understanding of the basic pathophysiology underlying the development of steatosis, steatohepatitis, fibrosis, cirrhosis, and HCC can better treatments evolve for liver diseases.

Potential topics include but are not limited to the following:

  • Classical mechanisms of liver damage
  • Inflammatory response during CLDs
  • Sources and triggers of ROS and inflammation during CLDs
  • Methods to evaluate oxidative stress and/or inflammation in the liver
  • Participation of ROS and/or inflammation on liver diseases spectrum (steatosis, fibrosis, cirrhosis, and/or cancer)
  • Participation of oxidative stress in alcoholic and nonalcoholic liver disease
  • Recent advances in the treatment of CLDs
  • Pharmacological treatments for CLDs
  • Traditional and herbal therapy for CLDs
  • Diagnosis and management of liver diseases
  • Recent advances in transplant surgery
  • Other areas of redox biology which may pave the way for further investigations of the ROS/RNS interplay in viral, bacterial, and parasitic disease

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 3140673
  • - Editorial

Oxidative Stress and Inflammation in Hepatic Diseases: Current and Future Therapy

Karina Reyes-Gordillo | Ruchi Shah | Pablo Muriel
  • Special Issue
  • - Volume 2017
  • - Article ID 3876040
  • - Research Article

Antioxidants of Phyllanthus emblica L. Bark Extract Provide Hepatoprotection against Ethanol-Induced Hepatic Damage: A Comparison with Silymarin

Renuka Chaphalkar | Kishori G. Apte | ... | Mukesh Nandave
  • Special Issue
  • - Volume 2017
  • - Article ID 1838679
  • - Research Article

Apolipoprotein CIII Overexpression-Induced Hypertriglyceridemia Increases Nonalcoholic Fatty Liver Disease in Association with Inflammation and Cell Death

Adriene A. Paiva | Helena F. Raposo | ... | Helena C. F. Oliveira
  • Special Issue
  • - Volume 2016
  • - Article ID 1840513
  • - Research Article

Low-ω3 Fatty Acid and Soy Protein Attenuate Alcohol-Induced Fatty Liver and Injury by Regulating the Opposing Lipid Oxidation and Lipogenic Signaling Pathways

Karina Reyes-Gordillo | Ruchi Shah | ... | M. Raj Lakshman
  • Special Issue
  • - Volume 2016
  • - Article ID 4234061
  • - Review Article

Insights into the Role and Interdependence of Oxidative Stress and Inflammation in Liver Diseases

Sha Li | Ming Hong | ... | Yibin Feng
  • Special Issue
  • - Volume 2016
  • - Article ID 6841348
  • - Research Article

Redox Control of Antioxidant and Antihepatotoxic Activities of Cassia surattensis Seed Extract against Paracetamol Intoxication in Mice: In Vitro and In Vivo Studies of Herbal Green Antioxidant

U. Seeta Uthaya Kumar | Yeng Chen | ... | Sreenivasan Sasidharan
  • Special Issue
  • - Volume 2016
  • - Article ID 4047362
  • - Research Article

Colonic and Hepatic Modulation by Lipoic Acid and/or N-Acetylcysteine Supplementation in Mild Ulcerative Colitis Induced by Dextran Sodium Sulfate in Rats

Fabiana Andréa Moura | Kívia Queiroz de Andrade | ... | Marília Oliveira Fonseca Goulart
  • Special Issue
  • - Volume 2016
  • - Article ID 7891574
  • - Review Article

Oxidative Stress and Liver Cancer: Etiology and Therapeutic Targets

Zhanpeng Wang | Zhuonan Li | ... | Wei Li
  • Special Issue
  • - Volume 2016
  • - Article ID 3178562
  • - Research Article

Renalase as a Novel Biomarker for Evaluating the Severity of Hepatic Ischemia-Reperfusion Injury

Huili Li | Jianrong Guo | ... | Jiliang Wang
  • Special Issue
  • - Volume 2016
  • - Article ID 6171658
  • - Review Article

Schisandrin B: A Double-Edged Sword in Nonalcoholic Fatty Liver Disease

Pou Kuan Leong | Kam Ming Ko
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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