Oxidative Medicine and Cellular Longevity

Oxidative Stress and Reprogramming of Mitochondrial Function and Dynamics as Targets to Modulate Cancer Cell Behavior and Chemoresistance


Publishing date
01 Jul 2019
Status
Published
Submission deadline
01 Mar 2019

Lead Editor

1University of L’Aquila, L’Aquila, Italy

2University of Salford, Salford, UK

3University of Genoa, Genoa, Italy


Oxidative Stress and Reprogramming of Mitochondrial Function and Dynamics as Targets to Modulate Cancer Cell Behavior and Chemoresistance

Description

Today, the cure of oncological patients encounters significant obstacles due to the development of chemoresistance, which, along with metastatic behavior, is thought to require extensive reprogramming of mitochondrial activity. The balance of fission and fusion, along with the regulation of trafficking and autophagic removal, dictates mitochondrial morphology and function, and this may have a deep impact on redox homeostasis and antioxidant defense of cancer cells, as well as on their apoptotic response to oxidative stress-generating and DNA-damaging anticancer drugs.

Evidence shows that natural molecules, such as curcumin and sulforaphane, modulate the response of cancer cells to anticancer therapies. However, limited reports exist with regard to the role of mitochondrial reprogramming in such a phenomenon. Therefore, molecular events activated in cancer cells by chemosensitizers need to be studied with regard to the possible participation of the main regulators of mitochondrial dynamics and function.

Such studies may lead to diet-based approaches aimed at repressing adaptive responses of mitochondria following chemotherapy, thus contributing to an increase in the efficacy of anticancer strategies.

On this basis, we invite researchers to submit original research and review articles focused on chemical strategies aimed at controlling the activity of antioxidant systems, as well as preventing the acquisition of chemoresistance in cancer cells, through morphofunctional reshaping of mitochondria and/or by modifying mitochondrial-regulated redox homeostasis. Studies reporting innovative techniques to visualize or analyze mitochondrial dynamics, cellular redox status, and reactive oxygen species- (ROS-) dependent cell damage are highly appreciated as well.

Potential topics include but are not limited to the following:

  • Studies on the effects of bioactive compounds on redox homeostasis, mitochondrial activity, and function of cancer cells, with possible consequences on malignant behavior
  • Investigations on the effects of synthetic or natural compounds on mitochondrial dynamics in neoplastic tissues or cancer cells, with particular focus on processes controlling mitochondrial fusion, fission, and autophagic removal
  • Studies with synthetic or natural compounds used to limit or prevent the neoplastic progression through the modulation of redox homeostasis, mitochondrial function, or activity, with particular focus on changes in the ROS-modulated metabolic rewiring and mitochondrial reshaping
  • Innovative imaging techniques to analyze mitochondria dynamics, metabolism, energy, and redox state in normal and cancer cells
  • Studies comparing neoplastic tissues or cancer cells of similar origin but with different aggressiveness, focusing on the redox-modulated pathways controlling mitochondrial function and dynamics

Articles

  • Special Issue
  • - Volume 2019
  • - Article ID 4647807
  • - Editorial

Oxidative Stress and Reprogramming of Mitochondrial Function and Dynamics as Targets to Modulate Cancer Cell Behavior and Chemoresistance

Stefano Falone | Michael P. Lisanti | Cinzia Domenicotti
  • Special Issue
  • - Volume 2019
  • - Article ID 8730816
  • - Review Article

LKB1/AMPK Pathway and Drug Response in Cancer: A Therapeutic Perspective

Francesco Ciccarese | Elisabetta Zulato | Stefano Indraccolo
  • Special Issue
  • - Volume 2019
  • - Article ID 7831952
  • - Review Article

Cancer Etiology: A Metabolic Disease Originating from Life’s Major Evolutionary Transition?

B. Poljsak | V. Kovac | ... | A. Starc
  • Special Issue
  • - Volume 2019
  • - Article ID 8781690
  • - Research Article

Betulinic Acid Suppresses Breast Cancer Metastasis by Targeting GRP78-Mediated Glycolysis and ER Stress Apoptotic Pathway

Yifeng Zheng | Pengxi Liu | ... | Zhiyu Wang
  • Special Issue
  • - Volume 2019
  • - Article ID 8576961
  • - Research Article

Oleuropein-Induced Apoptosis Is Mediated by Mitochondrial Glyoxalase 2 in NSCLC A549 Cells: A Mechanistic Inside and a Possible Novel Nonenzymatic Role for an Ancient Enzyme

Cinzia Antognelli | Roberta Frosini | ... | Vincenzo N. Talesa
  • Special Issue
  • - Volume 2019
  • - Article ID 7346492
  • - Review Article

MYC Expression and Metabolic Redox Changes in Cancer Cells: A Synergy Able to Induce Chemoresistance

Barbara Marengo | Ombretta Garbarino | ... | Cinzia Domenicotti
  • Special Issue
  • - Volume 2019
  • - Article ID 1659468
  • - Research Article

Oxidative Stress Induced by the Deubiquitinase Inhibitor b-AP15 Is Associated with Mitochondrial Impairment

Xiaonan Zhang | Belén Espinosa | ... | Stig Linder
  • Special Issue
  • - Volume 2019
  • - Article ID 6797921
  • - Research Article

Increased Oxidative Stress Induced by Rubus Bioactive Compounds Induce Apoptotic Cell Death in Human Breast Cancer Cells

Blassan P. George | Heidi Abrahamse
  • Special Issue
  • - Volume 2019
  • - Article ID 9051542
  • - Review Article

ROS-Mediated Cancer Cell Killing through Dietary Phytochemicals

Saranya NavaneethaKrishnan | Jesusa L. Rosales | Ki-Young Lee
  • Special Issue
  • - Volume 2019
  • - Article ID 3685817
  • - Research Article

Bloom Syndrome Protein Activates AKT and PRAS40 in Prostate Cancer Cells

Kun Chen | Houqiang Xu | Jiafu Zhao
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate44%
Submission to final decision78 days
Acceptance to publication39 days
CiteScore4.520
Impact Factor4.868
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