Oxidative Medicine and Cellular Longevity

Molecular Basis of Redox Signaling


Publishing date
01 Feb 2019
Status
Published
Submission deadline
28 Sep 2018

Lead Editor

1Oregon State University, Corvallis, USA

2Universidad de Buenos Aires, Buenos Aires, Argentina

3University Medical Center Freiburg, Freiburg im Breisgau, Germany


Molecular Basis of Redox Signaling

Description

While oxidative stress produces cellular damage due to the unspecific oxidation of a myriad of biomolecules, redox signaling is mediated by reactive oxygen and nitrogen species (ROS and RNS, resp.) acting as second messengers. Current efforts continue to broaden our comprehension of redox signaling as a series of highly specific, controlled and dynamic events mediated by electron transfer reactions that modify acceptor biomolecules either reversibly or irreversibly. This selective oxidation of specific targets regulates signaling pathways controlling a number of cellular processes, from metabolism to cell growth, differentiation, and death. Impaired redox signaling has been linked to pathological conditions where cellular damage is caused or mediated by the modification of critical biomolecules, resulting in gain or loss of function. Because redox signaling is an intrinsic component of human metabolism, its disruption is thought to contribute to the onset and progression of a variety of disorders. Due to their severity and rapidly growing investigation, the study of metabolic and neurodegenerative diseases provide an excellent platform to uncover the molecular basis of redox signaling.

We invite authors to submit original research articles as well as review articles that will contribute to broaden the understanding of the biochemical, cellular, and molecular mechanisms regulated by redox signaling. We are particularly interested in articles covering the identification of relevant targets and mechanisms regulated by redox signaling that could be exploited for therapeutic development.

Potential topics include but are not limited to the following:

  • Identification and characterization of molecular mediators of redox signaling
  • Redox sensors
  • Effect of oxidative modified molecules on energy metabolism
  • Effect of posttranslational oxidative modifications on protein function
  • Recent advances in antioxidant therapies

Articles

  • Special Issue
  • - Volume 2019
  • - Article ID 6414975
  • - Editorial

Molecular Basis of Redox Signaling

Maria Clara Franco | Maria C. Carreras | Luciana Hannibal
  • Special Issue
  • - Volume 2019
  • - Article ID 1701478
  • - Research Article

Enhancement by Hydrogen Peroxide of Calcium Signals in Endothelial Cells Induced by 5-HT1B and 5-HT2B Receptor Agonists

Pavel V. Avdonin | Alexander D. Nadeev | ... | Nikolay V. Goncharov
  • Special Issue
  • - Volume 2019
  • - Article ID 8472346
  • - Research Article

Markers of Oxidant-Antioxidant Equilibrium in Patients with Sudden Sensorineural Hearing Loss Treated with Hyperbaric Oxygen Therapy

Jarosław Paprocki | Paweł Sutkowy | ... | Alina Woźniak
  • Special Issue
  • - Volume 2019
  • - Article ID 2348165
  • - Research Article

Increased Transfection of the Easily Oxidizable GC-Rich DNA Fragments into the MCF7 Breast Cancer Cell

Svetlana V. Kostyuk | Nadezhda N. Mordkovich | ... | Serguey I. Kutsev
  • Special Issue
  • - Volume 2019
  • - Article ID 7017363
  • - Research Article

Cold Physical Plasma Modulates p53 and Mitogen-Activated Protein Kinase Signaling in Keratinocytes

Anke Schmidt | Sander Bekeschus | ... | Kristian Wende
  • Special Issue
  • - Volume 2018
  • - Article ID 4829872
  • - Research Article

Nucleoredoxin-Dependent Targets and Processes in Neuronal Cells

Claudia Urbainsky | Rolf Nölker | ... | Christopher Horst Lillig
  • Special Issue
  • - Volume 2018
  • - Article ID 1054797
  • - Review Article

The Tryptophan Pathway Targeting Antioxidant Capacity in the Placenta

Kang Xu | Gang Liu | Chenxing Fu
  • Special Issue
  • - Volume 2018
  • - Article ID 6290931
  • - Review Article

Hydrogen Sulfide Biochemistry and Interplay with Other Gaseous Mediators in Mammalian Physiology

Alessandro Giuffrè | João B. Vicente
  • Special Issue
  • - Volume 2018
  • - Article ID 8309698
  • - Research Article

Nrf2 Deficiency Unmasks the Significance of Nitric Oxide Synthase Activity for Cardioprotection

Ralf Erkens | Tatsiana Suvorava | ... | Miriam M. Cortese-Krott
  • Special Issue
  • - Volume 2018
  • - Article ID 7569127
  • - Research Article

L-Arginine Enhances Protein Synthesis by Phosphorylating mTOR (Thr 2446) in a Nitric Oxide-Dependent Manner in C2C12 Cells

Ruxia Wang | Hongchao Jiao | ... | Hai Lin
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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