Oxidative Medicine and Cellular Longevity

Salivary Redox Homeostasis and Oxidative Stress


Publishing date
01 Jan 2020
Status
Closed
Submission deadline
13 Sep 2019

Lead Editor

1Medical University of Bialystok, Białystok, Poland

2Universidad Complutense de Madrid, Madrid, Spain

This issue is now closed for submissions.
More articles will be published in the near future.

Salivary Redox Homeostasis and Oxidative Stress

This issue is now closed for submissions.
More articles will be published in the near future.

Description

The oral cavity is subjected to many biological, chemical, and physical factors such as xenobiotics, air pollutants, food, and pathogenic microorganisms. Therefore, the oral environment is particularly susceptible to oxidative stress, defined as an imbalance between the formation of reactive oxygen species (ROS) and the impaired function of the antioxidant defense systems. It is not surprising that saliva produced by salivary glands is a rich source of enzymatic and nonenzymatic antioxidants including salivary peroxidase (Px), catalase (CAT), superoxide dismutase (SOD), and myeloperoxidase, as well as uric acid, albumin, transferrin, and ceruloplasmin. The oral cavity is thus the first defense of the body against ROS overproduction and associated oxidative damage.

Oxidative stress plays a key role in the pathogenesis of many systemic and oral diseases. Interestingly, this process also impairs the secretory function of the salivary glands. Indeed, disturbances in salivary flow and salivary secretion have been demonstrated in subjects with obesity, diabetes, chronic kidney disease, Sjögren’s syndrome, or neuropsychiatric disorders, which can also explain the increased incidence on xerostomia, periodontitis, precancerous conditions, and cancer of the oral cavity in these groups of patients. Additionally, the results of recent studies indicate the usefulness of various oxidative stress biomarkers in the diagnosis of many pathological conditions; however, saliva is an especially attractive diagnostic material, in particular when compared to blood or cerebrospinal fluid. Nevertheless, still little is known about the salivary redox homeostasis both in healthy subjects and in the course of many systemic and oral diseases. Additionally, there is a lack of research on the impact of antioxidant supplementation on oxidative stress both at the central level and at salivary redox balance.

In this special issue, we will focus on recent advances in the contribution of oxidative stress to salivary redox hemostasis and function of the salivary glands. Novel ideas to discover further salivary redox biomarkers and potential applications will also be described. We welcome original research and review articles.

Potential topics include but are not limited to the following:

  • Salivary antioxidant defense and oxidative damage in oral and systemic diseases
  • Crosstalk between salivary and central redox homeostasis
  • Mechanisms underlying the impaired function of the salivary glands in oxidative stress-related diseases
  • Salivary redox biomarkers in the diagnosis of oral and systemic diseases
  • The effects of antioxidant supplementation on salivary and central redox balance
  • Mechanisms underlying the effects of natural and synthetic antioxidants on salivary redox systems
  • Animal models to study salivary oxidative stress
  • Salivary redox homeostasis in human health

Articles

  • Special Issue
  • - Volume 2020
  • - Article ID 3695683
  • - Research Article

Carious Lesion Severity Induces Higher Antioxidant System Activity and Consequently Reduces Oxidative Damage in Children’s Saliva

Heitor Ceolin Araujo | Ana Cláudia Melo Stevanato Nakamune | ... | Cristina Antoniali
  • Special Issue
  • - Volume 2020
  • - Article ID 5478708
  • - Review Article

Oxidative Stress in the Pathophysiology of Kidney Disease: Implications for Noninvasive Monitoring and Identification of Biomarkers

Marianna Gyurászová | Radana Gurecká | ... | Ľubomíra Tóthová
  • Special Issue
  • - Volume 2020
  • - Article ID 2852181
  • - Research Article

L-Glutamine Supplementation Improves the Benefits of Combined-Exercise Training on Oral Redox Balance and Inflammatory Status in Elderly Individuals

Ewin B. Almeida | Juliana M. B. Santos | ... | André L. L. Bachi
  • Special Issue
  • - Volume 2020
  • - Article ID 8948723
  • - Research Article

Effects of Tomato Juice Intake on Salivary 8-Oxo-dG Levels as Oxidative Stress Biomarker after Extensive Physical Exercise

Ali Pour Khavari | Siamak Haghdoost
  • Special Issue
  • - Volume 2020
  • - Article ID 9086024
  • - Research Article

Salivary Antioxidants and Oxidative Stress in Psoriatic Patients: Can Salivary Total Oxidant Status and Oxidative Status Index Be a Plaque Psoriasis Biomarker?

Anna Skutnik-Radziszewska | Mateusz Maciejczyk | ... | Anna Zalewska
  • Special Issue
  • - Volume 2019
  • - Article ID 4393460
  • - Research Article

Salivary Antioxidant Barrier, Redox Status, and Oxidative Damage to Proteins and Lipids in Healthy Children, Adults, and the Elderly

Mateusz Maciejczyk | Anna Zalewska | Jerzy Robert Ładny
  • Special Issue
  • - Volume 2019
  • - Article ID 5801570
  • - Research Article

The Relationship between the Concentration of Salivary Tyrosine and Antioxidants in Patients with Oral Lichen Planus

Dagmara Darczuk | Wirginia Krzyściak | ... | Tomasz Kaczmarzyk
  • Special Issue
  • - Volume 2019
  • - Article ID 5425021
  • - Research Article

Salivary and Plasmatic Antioxidant Profile following Continuous, Resistance, and High-Intensity Interval Exercise: Preliminary Study

Adriele V. Souza | Jéssica S. Giolo | ... | Foued S. Espindola
  • Special Issue
  • - Volume 2019
  • - Article ID 3403264
  • - Research Article

The Protective Impact of Black Chokeberry Fruit Extract (Aronia melanocarpa L.) on the Oxidoreductive System of the Parotid Gland of Rats Exposed to Cadmium

Zofia Dąbrowska | Ewa Dąbrowska | ... | Małgorzata Pietruska
  • Special Issue
  • - Volume 2019
  • - Article ID 2606120
  • - Research Article

The Impact of High-Fat Diet on Mitochondrial Function, Free Radical Production, and Nitrosative Stress in the Salivary Glands of Wistar Rats

Anna Zalewska | Dominika Ziembicka | ... | Mateusz Maciejczyk
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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