Oxidative Medicine and Cellular Longevity

Oxidative Stress and Antioxidant Strategies in Inflammatory Lung Diseases


Publishing date
01 Jun 2022
Status
Closed
Submission deadline
21 Jan 2022

Lead Editor
Guest Editors

1The First Hospital of Jilin University, Changchun, China

2Chinese PLA General Hospital, Beijing, China

3Massachusetts Institute of Technology, Cambridge, USA

This issue is now closed for submissions.
More articles will be published in the near future.

Oxidative Stress and Antioxidant Strategies in Inflammatory Lung Diseases

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Inflammatory lung diseases (ILDs) are diseases characterized by acute and chronic alveolar and/or bronchial inflammation of the lung. Diseases include chronic obstructive pulmonary disease (COPD), asthma, acute lung injury (ALI), and airway infected with bacteria, viruses, or fungi.

Although the pathogenesis of these diseases has not yet been fully understood, evidence suggests that oxidative stress plays a pivotal role in ILDs. Excessive reactive oxygen species (ROS) accumulation in the airway is associated with the occurrence, progression, disease severity, and pathological changes of ILDs. Therefore, therapeutic strategies targeting oxidative stress may be useful in ILDs treatment. Although proven to be effective in preclinical and basic studies, supplementation with antioxidant agents showed limited benefits in the clinical treatment of ILDs. This is most likely due to the complexity of oxidative stress in the pathogenesis of ILDs and the inefficient drug delivery pattern in the lungs. Therefore, more studies on the mechanisms underlying oxidative stress injury and new drug delivery systems in the lungs need to be further conducted so that there are more opportunities for the treatment of ILDs in clinical settings.

This Special Issue aims to collect original research and review articles relating to current studies on oxidative stress and antioxidant strategies in ILDs. Researchers and clinicians are invited to submit articles relating to basic, translational, or clinical research. The research in question should investigate the pathophysiology of ILDs. Moreover, submissions discussing novel or repositioning drugs targeting oxidative stress for the treatment of ILDs are highly encouraged. Submissions discussing new methodologies for drug delivery (e.g., nanoparticles, liposomes, dendrimers, solid lipid nanocarriers, etc.) are also welcome.

Potential topics include but are not limited to the following:

  • Cellular and molecular signals underlying oxidative stress
  • The crosstalk of oxidative stress, inflammation, and immune response in ILDs
  • The regulatory role of noncoding RNAs in oxidative stress
  • Genomics, proteomics, and metabolomics related to oxidative stress in ILDs
  • Physical and molecular biomarkers probing the redox status in lung airways
  • Theoretical and bioinformatics studies on oxidative stress in ILDs
  • Use of natural products with antioxidant activity for the treatment of ILDs
  • Small molecules or monoclonal antibodies against oxidative stress for the treatment of ILDs
  • Novel drug delivery strategies targeting oxidative stress in lungs
  • Clinical or preclinical studies on monitoring and intervening redox status in ILDs

Articles

  • Special Issue
  • - Volume 2022
  • - Article ID 9493710
  • - Research Article

MicroRNA-1224-5p Aggravates Sepsis-Related Acute Lung Injury in Mice

Bing Liu | Feng Chen | ... | Ming Xu
  • Special Issue
  • - Volume 2022
  • - Article ID 5044356
  • - Research Article

Inhalation of Salvianolic Acid B Prevents Fine Particulate Matter-Induced Acute Airway Inflammation and Oxidative Stress by Downregulating the LTR4/MyD88/NLRP3 Pathway

Yan Guan | Liucheng Li | ... | Qiangmin Xie
  • Special Issue
  • - Volume 2022
  • - Article ID 5475832
  • - Research Article

Adipose-Derived Circulating Exosomes Promote Protection of the Pulmonary Endothelial Barrier by Inhibiting EndMT and Oxidative Stress through Down-Regulation of the TGF-β Pathway: A Potential Explanation for the Obesity Paradox in ARDS

Di Qi | Wang Deng | ... | Qian Yu
  • Special Issue
  • - Volume 2022
  • - Article ID 5918954
  • - Research Article

Magnesium Hydride Ameliorates Endotoxin-Induced Acute Respiratory Distress Syndrome by Inhibiting Inflammation, Oxidative Stress, and Cell Apoptosis

Xuan Shi | Lina Zhu | ... | Xin Lv
  • Special Issue
  • - Volume 2022
  • - Article ID 3618806
  • - Review Article

PM2.5 Exposure and Asthma Development: The Key Role of Oxidative Stress

Kaimeng Liu | Shucheng Hua | Lei Song
  • Special Issue
  • - Volume 2022
  • - Article ID 6339355
  • - Research Article

Endogenous Sulfur Dioxide Improves the Survival Rate of Sepsis by Improving the Oxidative Stress Response during Lung Injury

Zhiwei Liu | Jiaqi Gao | ... | Bin Zhao
  • Special Issue
  • - Volume 2022
  • - Article ID 3990607
  • - Research Article

Zingerone Inhibits the Neutrophil Extracellular Trap Formation and Protects against Sepsis via Nrf2-Mediated ROS Inhibition

Yingjie Zhu | Dexiang Wang | ... | Dan Li
Oxidative Medicine and Cellular Longevity
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CiteScore9.300
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Article of the Year Award: Outstanding research contributions of 2021, as selected by our Chief Editors. Read the winning articles.