Oxidative Medicine and Cellular Longevity

Interplay between ROS and Autophagy in Cancer and Aging: From Molecular Mechanisms to Novel Therapeutic Approaches


Publishing date
01 Jul 2019
Status
Published
Submission deadline
22 Feb 2019

Lead Editor

1Institute for Advanced Studies in Nanoscience, Madrid, Spain

2University of Verona, Verona, Italy

3University of Rome “La Sapienza”, Rome, Italy

4University Hospital Munich-LMU, Munich, Germany

5National Centre for Cardiovascular Research (CNIC), Madrid, Spain


Interplay between ROS and Autophagy in Cancer and Aging: From Molecular Mechanisms to Novel Therapeutic Approaches

Description

Aging and cancer are highly related biological phenomena. Many cellular processes including DNA damage responses, increasing oxidative stress, metabolic rewiring, and cellular senescence that underpin several malignant phenotypic traits also contribute to the aging phenotype. Reactive Oxygen Species (ROS) are persistently elevated in cancer cells as a result of their increased metabolic activity, mitochondrial dysfunction, and activation of oncogenes. Autophagy comprises salvaging processes, commonly triggered by metabolic stress responses, by which macromolecules and organelles are targeted by autophagic vesicles to lysosomes for degradation and recycling of their constituents. Many studies reveal that alterations in ROS and autophagy are implicated in cancer biology and aging. However, while it is established that high levels of ROS and impaired autophagy drive aging in mammalian cells, their role in regulating cancer cell death or survival is highly contextual and dependent on the source of stress, tumour particularities, and its metabolic status. Despite the fact that both ROS and autophagy can promote tumorigenesis and cancer development, their exacerbation may induce cell death following a nonspecific injury or an excessive degradation of macromolecules and cellular organelles required for cellular processes. Interestingly, many oncogenic stimuli that induce ROS generation also induce autophagy, including nutrient starvation, mitochondrial dysfunction, and hypoxia, suggesting the existence of the interplay between ROS and autophagy. The understanding of the molecular mechanisms linking ROS and autophagy may acquire exceptional significance to develop novel, tailored preventive and therapeutic strategies against cancer disease and aging processes.

In this special issue, we invite researchers to contribute original research articles describing, or related to, novel cellular and molecular mechanisms mediated by ROS, and autophagy, as involved in cancer biology and aging. Studies characterizing specific crosstalk principles between ROS regulation and autophagy are particularly encouraged. Review articles describing the current state of the art are also welcome.

Potential topics include but are not limited to the following:

  • Role of ROS regulation in cancer biology, chemoresistance, and aging and molecular underpinnings thereof
  • Molecular basis of the interplay between ROS, autophagy, and metabolic dysfunction in cancer cells: from signaling pathways to functional impact
  • Role of ROS-driven lysosomal permeabilization as a mechanism for autophagy initiation
  • Role of mitophagy in cancer biology and aging, mechanisms underlying the interplay between mitophagy and oxidative stress, and nanotherapeutic applications aimed at restoring mitophagy
  • Innovative therapeutic approaches aimed at modulating and normalizing ROS levels and autophagy activation state in cancer cells: from nanotechnology to tailored medicine
  • Systems-level surveys for the integration of ROS regulation and autophagy with cell homeostasis

Articles

  • Special Issue
  • - Volume 2019
  • - Article ID 8794612
  • - Editorial

Interplay between ROS and Autophagy in Cancer and Aging: From Molecular Mechanisms to Novel Therapeutic Approaches

Marco Cordani | Massimo Donadelli | ... | Miguel Sánchez-Álvarez
  • Special Issue
  • - Volume 2019
  • - Article ID 5692958
  • - Research Article

Autophagy: A Player in response to Oxidative Stress and DNA Damage

Serena Galati | Christian Boni | ... | Annamaria Buschini
  • Special Issue
  • - Volume 2019
  • - Article ID 8753413
  • - Research Article

Ferritinophagic Flux Activation in CT26 Cells Contributed to EMT Inhibition Induced by a Novel Iron Chelator, DpdtpA

Yanjie Sun | Cuiping Li | ... | Changzheng Li
  • Special Issue
  • - Volume 2019
  • - Article ID 2641712
  • - Review Article

PARP1 and Poly(ADP-ribosyl)ation Signaling during Autophagy in Response to Nutrient Deprivation

José Manuel Rodríguez-Vargas | Francisco Javier Oliver-Pozo | Françoise Dantzer
  • Special Issue
  • - Volume 2019
  • - Article ID 4517091
  • - Research Article

Cucurbitacin B Exerts Antiaging Effects in Yeast by Regulating Autophagy and Oxidative Stress

Yanfei Lin | Yuki Kotakeyama | ... | Jianhua Qi
  • Special Issue
  • - Volume 2019
  • - Article ID 7096912
  • - Research Article

Tetramethylpyrazine Prevents Contrast-Induced Nephropathy via Modulating Tubular Cell Mitophagy and Suppressing Mitochondrial Fragmentation, CCL2/CCR2-Mediated Inflammation, and Intestinal Injury

Xuezhong Gong | Yiru Duan | ... | Tom K. Hei
  • Special Issue
  • - Volume 2019
  • - Article ID 6387357
  • - Review Article

Mitophagy and Oxidative Stress in Cancer and Aging: Focus on Sirtuins and Nanomaterials

Enza Vernucci | Carlo Tomino | ... | Matteo A. Russo
  • Special Issue
  • - Volume 2019
  • - Article ID 6050123
  • - Review Article

Oxidative Stress-Driven Autophagy acROSs Onset and Therapeutic Outcome in Hepatocellular Carcinoma

Fabio Ciccarone | Serena Castelli | Maria Rosa Ciriolo
  • Special Issue
  • - Volume 2019
  • - Article ID 1283075
  • - Review Article

Sestrins at the Interface of ROS Control and Autophagy Regulation in Health and Disease

Marco Cordani | Miguel Sánchez-Álvarez | ... | Massimo Donadelli
  • Special Issue
  • - Volume 2019
  • - Article ID 9675450
  • - Research Article

Hsp90 Inhibitor SNX-2112 Enhances TRAIL-Induced Apoptosis of Human Cervical Cancer Cells via the ROS-Mediated JNK-p53-Autophagy-DR5 Pathway

Liubing Hu | Yan Wang | ... | Zhong Liu
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
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Acceptance to publication37 days
CiteScore7.900
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