Oxidative Medicine and Cellular Longevity

Reactive Oxygen Species in Stem Cells


Status
Published

Lead Editor

1University of Modena and Reggio Emilia, Modena, Italy

2University of Florence, Florence, Italy

3Alma Mater Studiorum-University of Bologna, Bologna, Italy

4Drexel University College of Medicine, Philadelphia, USA


Reactive Oxygen Species in Stem Cells

Description

Stem cells are defined by their unique ability to self-renew and their multipotent differentiation capacity, thus maintaining tissue homeostasis throughout the life of a multicellular organism. Stem cells reside in niches characterized by hypoxia and low reactive oxygen species (ROS), both of which are critical for maintaining the potential for self-renewal and stemness. Moreover, stem cells display a metabolic profile different from that of terminally differentiated cells, showing a preference for the inefficient anaerobic metabolism. In fact, aerobic metabolism could generate an excess of ROS, leading to DNA damage, senescence, apoptosis, or cell death. Until recently, the focus in stem cell biology has been on the adverse effects of ROS, particularly the damaging effects of ROS accumulation on tissue aging and the development of cancer. However, it has become increasingly clear that, in some cases, redox status plays an important role in stem cell maintenance, that is, regulation of the cell cycle. In fact, ROS at low levels function as signaling molecules to mediate cell proliferation, migration, differentiation, and gene expression. ROS levels in stem and progenitor cells have a clear correlation with cellular functions and are regulated by a fine-tuning of the balance between ROS-generating and antioxidant defense systems. Molecular targets of ROS and distinct redox signaling pathways in stem and progenitor cells have been identified to activate transcription factors, such as Nrf2, ultimately determining cell fate. Thus, to fully decipher the underlying molecular mechanisms involved in the maintenance of stem cell self-renewal, it is critical to address the important role of redox homeostasis in the regulation of both self-renewal and differentiation of stem cells. Similar to normal stem cells, cancer stem cells (CSCs) also show lower intracellular ROS levels than non-CSCs, suggesting that maintenance of a reduced intracellular environment is associated with an undifferentiated state. However, the roles of ROS in CSCs remain poorly understood and intensive research for ROS in CSCs is desperately needed.

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the precise effects of ROS on stem cells in vitro and in vivo. We are particularly interested in articles describing the molecular mechanisms of action by which ROS modulate both normal and cancer stem cells properties.

Potential topics include, but are not limited to:

  • Role of ROS in maintaining the stemness capacity such as self-renewal
  • Role of ROS in determining differentiation potential
  • Role of ROS in causing senescence of stem cells and the stem cell niche
  • Role of ROS in regulating cancer stem cell properties

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 159080
  • - Editorial

Reactive Oxygen Species in Stem Cells

Tullia Maraldi | Cristina Angeloni | ... | Christian Sell
  • Special Issue
  • - Volume 2015
  • - Article ID 502105
  • - Research Article

Reactive Oxygen Species Are Required for Human Mesenchymal Stem Cells to Initiate Proliferation after the Quiescence Exit

O. G. Lyublinskaya | Ya. G. Borisov | ... | N. N. Nikolsky
  • Special Issue
  • - Volume 2015
  • - Article ID 105135
  • - Review Article

Controlling Redox Status for Stem Cell Survival, Expansion, and Differentiation

Sébastien Sart | Liqing Song | Yan Li
  • Special Issue
  • - Volume 2015
  • - Article ID 750798
  • - Review Article

Redox Regulation in Cancer Stem Cells

Shijie Ding | Chunbao Li | ... | Guanghong Zhou
  • Special Issue
  • - Volume 2015
  • - Article ID 101304
  • - Research Article

Nuclear Nox4 Role in Stemness Power of Human Amniotic Fluid Stem Cells

Tullia Maraldi | Marianna Guida | ... | Anto De Pol
  • Special Issue
  • - Volume 2015
  • - Article ID 486263
  • - Review Article

Reactive Oxygen Species in Mesenchymal Stem Cell Aging: Implication to Lung Diseases

Se-Ran Yang | Jeong-Ran Park | Kyung-Sun Kang
  • Special Issue
  • - Volume 2015
  • - Article ID 294303
  • - Review Article

Increased Oxidative Stress as a Selective Anticancer Therapy

Jiahui Liu | Zhichong Wang
  • Special Issue
  • - Volume 2015
  • - Article ID 782123
  • - Research Article

GC-Rich Extracellular DNA Induces Oxidative Stress, Double-Strand DNA Breaks, and DNA Damage Response in Human Adipose-Derived Mesenchymal Stem Cells

Svetlana Kostyuk | Tatiana Smirnova | ... | Natalia Veiko
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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