While oxidative stress produces cellular damage due to the non-specific oxidation of a myriad of biomolecules, redox signalling is mediated by reactive oxygen, nitrogen, and sulphur species acting as second messengers. Current efforts continue to broaden our comprehension of redox signalling as a series of highly specific, controlled, and dynamic events mediated by electron transfer reactions that modify acceptor biomolecules either reversibly or irreversibly. This selective oxidation of specific targets regulates signalling pathways controlling a number of cellular processes, from metabolism to cell growth, differentiation, and death. Impaired redox signalling has been linked to pathological conditions where cellular damage is caused or mediated by the modification of critical biomolecules, resulting in gain or loss of function.

Because redox signalling is an intrinsic component of human metabolism, its disruption is thought to contribute to the onset and progression of a variety of disorders. Due to their severity and rapidly growing investigation, the study of metabolic and neurodegenerative diseases provides an excellent platform to uncover the molecular basis of redox signalling.

This Special Issue invites authors to submit original research articles as well as review articles that will contribute to broadening the understanding of the biochemical, cellular, and molecular mechanisms regulated by redox signalling. We are particularly interested in articles covering the identification of relevant targets and mechanisms regulated by redox signalling that could be exploited for therapeutic development.

Potential topics include but are not limited to the following:

• Biological sources of redox reactive species
• Redox enzymes
• Redox sensors
• Novel biological targets for oxidation
• Identification of oxidatively modified molecules and antioxidants in cell metabolism
• Redox regulation of cell metabolism