Oxidative Medicine and Cellular Longevity

Cellular Models of Aging


Publishing date
19 Oct 2012
Status
Published
Submission deadline
01 Jun 2012

Lead Editor

1Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal

2Faculty of Biosciences and Cluster of Excellence Macromolecular Complexes, Department of Molecular Biosciences, Johann Wolfgang Goethe University, Frankfurt, Germany

3IBMC, Instituto de Biologia Molecular e Celular, Universidade do Porto, Portugal

4Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA


Cellular Models of Aging

Description

Aging is a multifactorial and complex process originating with alterations at the genetic, biochemical, and physiological levels that disrupt a broad range of cellular mechanisms in a complex fashion. Aging processes have been extensively studied in various model organisms and systems. Although results obtained from studies with any model system have to be viewed with caution when translated to human aging, much of the current understanding of conserved pathways involved in aging and lifespan control is derived from investigations with experimentally tractable models. Aging research has now reached a stage where it is possible to move from a reductionistic approach studying individual factors toward a more global analysis. With the recent development of technologies that allow for the generation and computational analyses of large sets of data, the ultimate goal is to unravel the various interacting molecular pathways governing aging and thus to elaborate a holistic understanding of this complex process.

We invite investigators to contribute original research articles as well as review articles describing current efforts directed at understanding the molecular mechanisms controlling aging. We are particularly interested in articles that explore aging mechanisms in cellular model system ranging from lower eukaryotic cells (e.g. fungi, nematodes, flies) to higher eukaryotic cells (e.g. human or mouse derived cells lines). Potential topics include, but are not limited to:

  • Molecular factors and pathways contributing to aging
  • Development and application of experimental and computational methods, including approaches of systems biology
  • Cellular biomarkers and cellular determinants of longevity
  • Oxidative damage and cellular surveillance systems
  • Mitochondrial function and aging
  • mRNA translation and aging
  • Genetic instability and aging

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/oximed/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 616128
  • - Editorial

Cellular Models of Aging

Paula Ludovico | Heinz D. Osiewacz | ... | William C. Burhans
  • Special Issue
  • - Volume 2012
  • - Article ID 728430
  • - Review Article

DNA Mismatch Repair System: Repercussions in Cellular Homeostasis and Relationship with Aging

Juan Cristóbal Conde-Pérezprina | Miguel Ángel León-Galván | Mina Konigsberg
  • Special Issue
  • - Volume 2012
  • - Article ID 458276
  • - Review Article

Therapeutic Targeting of Redox Signaling in Myofibroblast Differentiation and Age-Related Fibrotic Disease

Natalie Sampson | Peter Berger | Christoph Zenzmaier
  • Special Issue
  • - Volume 2012
  • - Article ID 919832
  • - Research Article

Protein Oxidative Damage at the Crossroads of Cellular Senescence, Aging, and Age-Related Diseases

Martin A. Baraibar | Liang Liu | ... | Bertrand Friguet
  • Special Issue
  • - Volume 2012
  • - Article ID 217594
  • - Research Article

Centrosome Aberrations Associated with Cellular Senescence and p53 Localization at Supernumerary Centrosomes

Susumu Ohshima
  • Special Issue
  • - Volume 2012
  • - Article ID 282438
  • - Review Article

Nuclear and Mitochondrial DNA Repair in Selected Eukaryotic Aging Model Systems

Ricardo Gredilla | Christian Garm | Tinna Stevnsner
  • Special Issue
  • - Volume 2012
  • - Article ID 321653
  • - Review Article

Pleiotropic Cellular Functions of PARP1 in Longevity and Aging: Genome Maintenance Meets Inflammation

Aswin Mangerich | Alexander Bürkle
  • Special Issue
  • - Volume 2012
  • - Article ID 310534
  • - Research Article

Persistent Amplification of DNA Damage Signal Involved in Replicative Senescence of Normal Human Diploid Fibroblasts

Masatoshi Suzuki | Keiji Suzuki | ... | Masami Watanabe
  • Special Issue
  • - Volume 2012
  • - Article ID 728547
  • - Review Article

Is Physical Activity Able to Modify Oxidative Damage in Cardiovascular Aging?

Graziamaria Corbi | Valeria Conti | ... | Nicola Ferrara
  • Special Issue
  • - Volume 2012
  • - Article ID 854502
  • - Research Article

Overexpression of Fatty-Acid- -Oxidation-Related Genes Extends the Lifespan of Drosophila melanogaster

Shin-Hae Lee | Su-Kyung Lee | ... | Kyung-Jin Min
Oxidative Medicine and Cellular Longevity
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Acceptance rate8%
Submission to final decision133 days
Acceptance to publication34 days
CiteScore10.100
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