Oxidative Medicine and Cellular Longevity

Oxidative Stress in Chronic Kidney Disease


Status
Published

1University of Southern Denmark, Odense, Denmark

2RWTH Aachen University Hospital, Aachen, Germany

3National Autonomous University of Mexico, Mexico City, Mexico

4KU Leuven, Leuven, Belgium


Oxidative Stress in Chronic Kidney Disease

Description

Chronic kidney disease (CKD) is associated with cardiovascular disease, muscle wasting, malnutrition, and chronic inflammation. In chronic kidney disease, oxidative stress occurs frequently and has been proposed as a central mechanism in the pathogenesis of CKD progression and CKD associated complications and mortality. There is a multitude of recently described relations between oxidative stress and molecular changes in CKD, as reduction of alpha-klotho, impaired vitamin-D signaling, and posttranslational protein modifications. It is a current challenge to determine for the particular prooxidant or antioxidant constituent which amount is adaptive, protective, or damaging at a certain disease state. Also, there is a definite need to determine which therapeutic interventions, which interfere with oxidant or antioxidant processes, result in a clinically detectable improvement in patients with CKD.

We invite investigators to contribute original research articles as well as review articles to advance our understanding about the role of oxidative stress in CKD. We are especially interested in results from controlled trials measuring clinical outcomes of antioxidant treatment and/or analyzing molecular changes that occur during treatment with antioxidant substances in CKD. We also encourage investigators to contribute their results about associations of the clinical outcome of patients with CKD and biomarkers of oxidative stress. Also, we invite authors to present their results from animal or cell models which help to understand how changes of a particular oxidant or antioxidant constituent in CKD result in damaging or protective effects.

Potential topics include, but are not limited to:

  • Treatment strategies to prevent development of oxidative stress in CKD
  • Clinical trials with antioxidant substances in CKD
  • Strategies to decrease the oxidative stress burden in CKD
  • Oxidative stress biomarker research in CKD
  • Molecular investigations of the effects of oxidative stress in CKD
  • Posttranslational protein modifications related to oxidative stress in CKD
  • Molecular investigations of the effects of antioxidant therapies in CKD

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 8375186
  • - Editorial

Oxidative Stress in Chronic Kidney Disease

Alexandra Scholze | Joachim Jankowski | ... | Pieter Evenepoel
  • Special Issue
  • - Volume 2016
  • - Article ID 8598253
  • - Review Article

Systemic Redox Imbalance in Chronic Kidney Disease: A Systematic Review

Konstantina P. Poulianiti | Antonia Kaltsatou | ... | Christina Karatzaferi
  • Special Issue
  • - Volume 2016
  • - Article ID 8490643
  • - Research Article

Oxidative Stress as Estimated by Gamma-Glutamyl Transferase Levels Amplifies the Alkaline Phosphatase-Dependent Risk for Mortality in ESKD Patients on Dialysis

Claudia Torino | Francesco Mattace-Raso | ... | PROGREDIRE Study Group
  • Special Issue
  • - Volume 2016
  • - Article ID 6043601
  • - Review Article

New Pathogenic Concepts and Therapeutic Approaches to Oxidative Stress in Chronic Kidney Disease

José Pedraza-Chaverri | Laura G. Sánchez-Lozada | ... | Alexandra Scholze
  • Special Issue
  • - Volume 2016
  • - Article ID 1507270
  • - Research Article

A Genetic Biomarker of Oxidative Stress, the Paraoxonase-1 Q192R Gene Variant, Associates with Cardiomyopathy in CKD: A Longitudinal Study

E. Dounousi | I. Bouba | ... | K. Siamopoulos
  • Special Issue
  • - Volume 2016
  • - Article ID 3592042
  • - Review Article

DNA Damage in Chronic Kidney Disease: Evaluation of Clinical Biomarkers

Nicole Schupp | Helga Stopper | August Heidland
  • Special Issue
  • - Volume 2016
  • - Article ID 1069743
  • - Review Article

Role of Myeloperoxidase in Patients with Chronic Kidney Disease

Bojana Kisic | Dijana Miric | ... | Ljiljana Popovic
  • Special Issue
  • - Volume 2016
  • - Article ID 7496930
  • - Research Article

MnTBAP Therapy Attenuates Renal Fibrosis in Mice with 5/6 Nephrectomy

Jing Yu | Song Mao | ... | Aihua Zhang
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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