Oxidative Medicine and Cellular Longevity

Role of Natural Antioxidants from Functional Foods in Neurodegenerative and Metabolic Disorders


Publishing date
13 Apr 2018
Status
Published
Submission deadline
24 Nov 2017

1Amapá Federal University, Amapá, Brazil

2Rio de Janeiro State University, Rio de Janeiro, Brazil

3Juiz de Fora Federal University, Minas Gerais, Brazil

4Sorbonne Universités, Paris, France

5University of Mississippi, Oxford, USA


Role of Natural Antioxidants from Functional Foods in Neurodegenerative and Metabolic Disorders

Description

The imbalance in formation of reactive oxygen species (ROS) is related to oxidative stress. Excessive ROS generated are involved in cellular proteins, lipids, and nucleic acids leading to cellular dysfunction including loss of energy metabolism, altered cell signalling and cell cycle control, genetic mutations, altered cellular transport mechanisms and overall decreased biological activity, immune activation, and inflammation.

Oxidative stress leading to free radical attack on neural cells contributes calamitous role in neurodegeneration. Though oxygen is imperative for life, imbalanced metabolism and excess of ROS generation lead to a range of disorders such as Alzheimer’s disease, Parkinson’s disease, aging, and many other neural disorders. Additionally, excess of ROS production is central to a variety of metabolic pathologies such as diabetes, obesity, aging, and other secondary complications associated with them. Diet is major source of antioxidants, and medicinal plants are catching attention to be commercial source of antioxidants.

Natural sources of antioxidant compounds are a wide range of secondary metabolites including carotenoids, flavonoids, anthocyanins, tannins, and others with great higher antioxidant capacity. Therefore, plant-based foods that contain natural sources of antioxidant compounds are a potential strategy to minimize oxidative stress related diseases.

Potential topics include but are not limited to the following:

  • In vitro and in vivo release profile of antioxidants from functional foods
  • Evaluation of functional foods on models of neurodegenerative or metabolic diseases induced by oxidative stress
  • Mechanism of action of functional foods on neurodegenerative or metabolic diseases
  • Protein expression induced by natural antioxidants from functional foods
  • Evaluation of toxicity/side effects of functional foods
  • Development of novel (e.g., nanostructured systems) functional food products
  • Nonclinical and clinical studies of functional foods

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 1459753
  • - Editorial

Role of Natural Antioxidants from Functional Foods in Neurodegenerative and Metabolic Disorders

José C. T. Carvalho | Caio P. Fernandes | ... | N. P. Dhammika Nanayakkara
  • Special Issue
  • - Volume 2018
  • - Article ID 7634362
  • - Research Article

Polyphenol Stilbenes from Fenugreek (Trigonella foenum-graecum L.) Seeds Improve Insulin Sensitivity and Mitochondrial Function in 3T3-L1 Adipocytes

Gang Li | Guangxiang Luan | ... | Honglun Wang
  • Special Issue
  • - Volume 2018
  • - Article ID 4120458
  • - Review Article

Recent Advances in Studies on the Therapeutic Potential of Dietary Carotenoids in Neurodegenerative Diseases

Kyoung Sang Cho | Myeongcheol Shin | ... | Sung Bae Lee
  • Special Issue
  • - Volume 2018
  • - Article ID 2189348
  • - Research Article

Methyl Chavicol and Its Synthetic Analogue as Possible Antioxidant and Antilipase Agents Based on the In Vitro and In Silico Assays

Bruna Celeida Silva Santos | Andressa Soares Pires | ... | Orlando Vieira de Sousa
  • Special Issue
  • - Volume 2018
  • - Article ID 2678089
  • - Research Article

Clarified Açaí (Euterpe oleracea) Juice as an Anticonvulsant Agent: In Vitro Mechanistic Study of GABAergic Targets

Gabriela P. F. Arrifano | Mathieu P. Lichtenstein | ... | Maria Elena Crespo-López
  • Special Issue
  • - Volume 2017
  • - Article ID 5863523
  • - Research Article

Antioxidant and Hepatoprotective Activities of Polysaccharides from Spent Mushroom Substrates (Laetiporus sulphureus) in Acute Alcohol-Induced Mice

Huajie Zhao | Yufei Lan | ... | Le Jia
  • Special Issue
  • - Volume 2017
  • - Article ID 2383157
  • - Research Article

Radical Scavenger Capacity of Jabuticaba Fruit (Myrciaria cauliflora) and Its Biological Effects in Hypertensive Rats

Camila Gabriela de Souza | Daniela Medeiros Lobo de Andrade | ... | Matheus Lavorenti Rocha
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision71 days
Acceptance to publication36 days
CiteScore4.520
Impact Factor4.868
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