Oxidative Medicine and Cellular Longevity

Oxidative Stress as a Link between Cerebrocardiovascular and Psychiatric Disorders


Publishing date
01 Mar 2020
Status
Published
Submission deadline
25 Oct 2019

Lead Editor

1University of Catania, Sicily, Italy

2University of Glasgow, Glasgow, UK


Oxidative Stress as a Link between Cerebrocardiovascular and Psychiatric Disorders

Description

Psychiatric disorders (i.e., depression and schizophrenia) show high rates of comorbidity with cardiovascular (i.e., coronary heart disease) and cerebrovascular (i.e., stroke) disturbances. The bond between these disorders is apparent in clinical practice. In fact, depression and anxiety independently predict cardiac events, which in turn represent a major cause of mortality in psychiatric disorders, the latter being frequently burdened by cerebrocardiovascular risk factors (i.e., smoking). On the other hand, depressive symptoms are extremely common in poststroke and vascular dementia. Interestingly, the link between cerebrocardiovascular and psychiatric disturbances could find an explanation at a molecular level, since both disorders share oxidative stress (OS) as a major contributor to their pathogenesis and progression.

From a cardiovascular perspective, OS is involved in the pathogenesis of several risk factors (i.e., obesity and hypertension), alters the function of blood vessels (damaging the vascular endothelium), and contributes to cardiac remodelling following myocardial infarction. Hence, a prooxidative condition favours the occurrence of cardiovascular disease but also its progression, being involved in the maladaptive response to cardiac injury.

Looking at neuropsychiatric aspects, OS contributes to the neuronal apoptosis and the disruption of the blood-brain barrier characterizing stroke, vascular dementia, and subarachnoid haemorrhage. On the other hand, it is involved in the pathogenesis of several psychiatric disorders (i.e., depression, bipolar disorder, and schizophrenia) through various mechanisms, such as synaptic alteration and circadian rhythm disruption.

Finally, from a molecular point of view, depressed patients frequently display a prooxidative profile favouring atherosclerosis (i.e., enhanced NADPH oxidase activity and high endoplasmic reticulum stress). In addition, hyperhomocysteinemia, a cerebrocardiovascular risk factor triggering OS, has been reported among patients suffering from schizophrenia. As a matter of fact, both psychiatric and cerebrocardiovascular disorders share OS as a common molecular basis, as well as several OS-related molecular abnormalities, such as enhanced oxidation of lipoproteins, low paraoxonase activity, and dysfunctional glycogen synthase kinase-3 beta. Interestingly, the proinflammatory and prooxidative properties of certain drugs could even explain why some psychopharmacological agents (such as antipsychotics) display a potential cardiotoxicity (i.e., QTc prolongation), while cardiac medications, such as reserpine and class I antiarrhythmics, could, respectively, lead to depressive and psychotic symptoms.

In this special issue, we are inviting researchers to contribute research articles and review articles that seek to address the role of oxidative stress as a link between cerebrocardiovascular and psychiatric disorders.

Potential topics include but are not limited to the following:

  • Occurrence and response to cardiac injury: the role of oxidative stress
  • Functional alterations of blood vessels: the role of oxidative stress
  • Oxidative stress and vascular dementia
  • Oxidative stress and poststroke depression
  • Oxidative stress and psychiatric drugs-induced cardiologic side effects
  • Oxidative stress and cardiologic drugs-induced psychiatric side effects
  • Oxidative stress as a link between cerebrocardiovascular and psychiatric disturbances

Articles

  • Special Issue
  • - Volume 2020
  • - Article ID 5685317
  • - Editorial

Oxidative Stress as a Link between Cerebrocardiovascular and Psychiatric Disorders

Maria Luca | Tomasz Guzik | Antonina Luca
  • Special Issue
  • - Volume 2020
  • - Article ID 9894037
  • - Research Article

Ganoderma lucidum Triterpenoids (GLTs) Reduce Neuronal Apoptosis via Inhibition of ROCK Signal Pathway in APP/PS1 Transgenic Alzheimer’s Disease Mice

Nanhui Yu | Yongpan Huang | ... | Yimin Zhu
  • Special Issue
  • - Volume 2020
  • - Article ID 4309605
  • - Research Article

Maternal Separation Induces Long-Term Alterations in the Cardiac Oxytocin Receptor and Cystathionine γ-Lyase Expression in Mice

Daniela C. Wigger | Nicole Gröger | ... | Christiane Waller
  • Special Issue
  • - Volume 2019
  • - Article ID 8067045
  • - Review Article

Oxidative Stress-Related Endothelial Damage in Vascular Depression and Vascular Cognitive Impairment: Beneficial Effects of Aerobic Physical Exercise

Maria Luca | Antonina Luca
  • Special Issue
  • - Volume 2019
  • - Article ID 9570616
  • - Review Article

Advanced Glycation End Products: Potential Mechanism and Therapeutic Target in Cardiovascular Complications under Diabetes

Ping Yang | Jian Feng | ... | Zhongcai Fan
  • Special Issue
  • - Volume 2019
  • - Article ID 2051235
  • - Research Article

NOX2-Dependent Reactive Oxygen Species Regulate Formyl-Peptide Receptor 1-Mediated TrkA Transactivation in SH-SY5Y Cells

Martina Castaldo | Cristiana Zollo | ... | Fabio Cattaneo
  • Special Issue
  • - Volume 2019
  • - Article ID 1684198
  • - Research Article

Modification of Immunological Parameters, Oxidative Stress Markers, Mood Symptoms, and Well-Being Status in CFS Patients after Probiotic Intake: Observations from a Pilot Study

Letizia Venturini | Sara Bacchi | ... | Chiara Cusa
  • Special Issue
  • - Volume 2019
  • - Article ID 2491927
  • - Review Article

The Role of Oxidative Stress in Common Risk Factors and Mechanisms of Cardio-Cerebrovascular Ischemia and Depression

Danfeng Lin | Lingling Wang | ... | Anwen Shao
  • Special Issue
  • - Volume 2019
  • - Article ID 4623109
  • - Review Article

Environmental Noise-Induced Effects on Stress Hormones, Oxidative Stress, and Vascular Dysfunction: Key Factors in the Relationship between Cerebrocardiovascular and Psychological Disorders

Omar Hahad | Jürgen H. Prochaska | ... | Thomas Münzel
  • Special Issue
  • - Volume 2019
  • - Article ID 9658267
  • - Research Article

Cerebroprotective Effect against Cerebral Ischemia of the Combined Extract of Oryza sativa and Anethum graveolens in Metabolic Syndrome Rats

Jintanaporn Wattanathorn | Warin Ohnon | ... | Terdthai Tong-un
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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