Oxidative Medicine and Cellular Longevity

Gasotransmitters in Biology and Medicine: Molecular Mechanisms and Drug Targets


Publishing date
16 Sep 2016
Status
Published
Submission deadline
29 Apr 2016

1Laurentian University, Sudbury, Canada

2Western University, London, Ontario, Canada

3Nanjing Medical University, Nanjing, China

4Shanxi University, Taiyuan, China

5University of Oregon, Eugene, USA


Gasotransmitters in Biology and Medicine: Molecular Mechanisms and Drug Targets

Description

In the last two decades, an increasing number of reports have indicated the remarkable roles of gasotransmitters in biology and medicine. Gasotransmitter is a group of small gaseous molecules, including nitric oxide (NO), hydrogen sulfide (H2S), and carbon monoxide (CO). Gasotransmitter has higher lipid solubility and can penetrate easily through cell membranes without using any specific transporter/receptor. Not only from the environment, gasotransmitter can also be endogenously generated by specific enzymes and generates various functions at physiologically relevant concentrations by targeting at specific cellular and molecular sites. Abnormal generation and metabolism of these gasotransmitters have been extensively demonstrated to be linked to diverse biological processes, such as vascular biology, immune functions, cellular survival, metabolism, longevity, and development and stress resistance.

In this specific issue, we cordially invite authors to contribute original research articles as well as review articles highlighting the novel discoveries and recent progress in relation to the molecular mechanisms and drug targets of gasotransmitters in biology and medicine as well as the involvement of gasotransmitters in response to environmental stress in plant.

Potential topics include, but are not limited to:

  • Gasotransmitters and cellular response to oxidative stress
  • The molecular mechanisms of gasotransmitters in both health and disease
  • The chemical and biochemical basis of gasotransmitters in cellular functions
  • Novel donors and detection methods for gasotransmitters
  • Generation, regulation, and metabolism of gasotransmitters in diverse biological systems
  • Targeting gasotransmitters for therapeutic purposes

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 4627308
  • - Editorial

Gasotransmitters in Biology and Medicine: Molecular Mechanisms and Drug Targets

Guangdong Yang | Alp Sener | ... | Michael D. Pluth
  • Special Issue
  • - Volume 2016
  • - Article ID 1607092
  • - Research Article

Functional Interactions between BKCaα-Subunit and Annexin A5: Implications in Apoptosis

Stephen P. Brazier | Vsevolod Telezhkin | Paul J. Kemp
  • Special Issue
  • - Volume 2016
  • - Article ID 4529060
  • - Review Article

Role of Endogenous Sulfur Dioxide in Regulating Vascular Structural Remodeling in Hypertension

Jia Liu | Yaqian Huang | ... | Junbao Du
  • Special Issue
  • - Volume 2016
  • - Article ID 7364138
  • - Review Article

Targeting Nitric Oxide with Natural Derived Compounds as a Therapeutic Strategy in Vascular Diseases

Maurizio Forte | Valeria Conti | ... | Albino Carrizzo
  • Special Issue
  • - Volume 2016
  • - Article ID 8128957
  • - Research Article

Hydrogen Sulfide Improves Endothelial Dysfunction via Downregulating BMP4/COX-2 Pathway in Rats with Hypertension

Lin Xiao | Jing-Hui Dong | ... | Yu-Ming Wu
  • Special Issue
  • - Volume 2016
  • - Article ID 1531392
  • - Research Article

AMP-Activated Protein Kinase Attenuates High Salt-Induced Activation of Epithelial Sodium Channels (ENaC) in Human Umbilical Vein Endothelial Cells

Wei-Wan Zheng | Xin-Yuan Li | ... | Zhi-Ren Zhang
  • Special Issue
  • - Volume 2016
  • - Article ID 4715651
  • - Research Article

Hydrogen Sulfide Alleviates Postharvest Senescence of Grape by Modulating the Antioxidant Defenses

Zhi-Jing Ni | Kang-Di Hu | ... | Hua Zhang
  • Special Issue
  • - Volume 2016
  • - Article ID 1730750
  • - Review Article

Gasotransmitters in Gametogenesis and Early Development: Holy Trinity for Assisted Reproductive Technology—A Review

Jan Nevoral | Jean-Francois Bodart | Jaroslav Petr
  • Special Issue
  • - Volume 2016
  • - Article ID 3285074
  • - Review Article

Implications of Hydrogen Sulfide in Glucose Regulation: How H2S Can Alter Glucose Homeostasis through Metabolic Hormones

Jennifer Pichette | Jeffrey Gagnon
  • Special Issue
  • - Volume 2016
  • - Article ID 9049782
  • - Review Article

Physiological Importance of Hydrogen Sulfide: Emerging Potent Neuroprotector and Neuromodulator

Sandesh Panthi | Hyung-Joo Chung | ... | Na Young Jeong
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.300
Impact Factor5.076
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