Oxidative Medicine and Cellular Longevity

Oxidative Stress-Mediated Reperfusion Injury: Mechanism and Therapies


Publishing date
27 Dec 2013
Status
Published
Submission deadline
09 Aug 2013

Lead Editor

1Department of Anesthesiology, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, Hong Kong

2Department of Pharmacology and Toxicology, Wright State University Boonshoft School of Medicine, 210 Health Sciences, 3640 Colonel Glenn Highway, Dayton, OH 45435, USA

3Department of Cardiology, Affiliated Beijing AnZhen Hospital of Capital University of Medical Sciences, No. 3 Anzhen Li, Beijing 100029, China

4Department of Cell Biology & Anatomy, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada


Oxidative Stress-Mediated Reperfusion Injury: Mechanism and Therapies

Description

Oxidative stress plays an important role in the pathogenesis of ischemia reperfusion injury. The mechanisms underlying ischaemia/reperfusion injury have been extensively studied using healthy tissues, yet less attention has been devoted to defining how the different risk factors such as diabetes and aging (situations that are associated with increased oxidative stress) may influence the degree of organ or cellular injury under pathological conditions like ischemia/reperfusion. While rapid production of large amount of reactive oxygen species (ROS), called oxidative burst, causes oxidative damage which contributes significantly to ischemia reperfusion injury, moderate elevation of ROS production induced by therapeutic interventions like ischemic or pharmacologic preconditioning may trigger cellular protective signaling pathways, leading to the attenuation of ischemia reperfusion injury.

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the molecular mechanism underlying ischemia/reperfusion injury under normal and diseased conditions to develop strategies to treat these pathological conditions. Potential topics include, but are not limited to:

  • Role of reactive oxygen species (ROS) in organ (heart, lung, brain, liver, kidney, and/or intestine) ischemia reperfusion injury under normal and diseased (e.g., diabetes and hypertension) conditions
  • Cellular protective signaling pathways that ROS may trigger that contribute to cellular repairing during ischemia reperfusion injury and the potential interplay between these pathways
  • Cardioprotection in aged and/or functionally impaired hearts
  • Role of reperfusion-induced oxidative stress and inflammation in mediating remote organ injury
  • Recent advances in preventing ischemia-reperfusion injury

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/oximed/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/oximed/oxin/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2013
  • - Article ID 678484
  • - Research Article

Nitroglycerine-Induced Nitrate Tolerance Compromises Propofol Protection of the Endothelial Cells against TNF-α: The Role of PKC-β2 and NADPH Oxidase

Shaoqing Lei | Wating Su | ... | Zhengyuan Xia
  • Special Issue
  • - Volume 2013
  • - Article ID 432409
  • - Research Article

Early Growth Response Protein 1 Promotes Restenosis by Upregulating Intercellular Adhesion Molecule-1 in Vein Graft

Kui Zhang | Jian Cao | ... | Jie Du
  • Special Issue
  • - Volume 2013
  • - Article ID 692302
  • - Research Article

The Effect of Safflower Yellow on Spinal Cord Ischemia Reperfusion Injury in Rabbits

Daiwei Zhou | Bingbing Liu | ... | Weihua Huang
  • Special Issue
  • - Volume 2013
  • - Article ID 185715
  • - Research Article

Resolvin D1 Reverts Lipopolysaccharide-Induced TJ Proteins Disruption and the Increase of Cellular Permeability by Regulating I κBα Signaling in Human Vascular Endothelial Cells

Xingcai Zhang | Tingting Wang | ... | Qingping Wu
  • Special Issue
  • - Volume 2013
  • - Article ID 859056
  • - Research Article

Transient Limb Ischemia Alters Serum Protein Expression in Healthy Volunteers: Complement C3 and Vitronectin May Be Involved in Organ Protection Induced by Remote Ischemic Preconditioning

Ting Pang | Yang Zhao | ... | San-Qiang Pan
  • Special Issue
  • - Volume 2013
  • - Article ID 943416
  • - Clinical Study

Aging Might Increase the Incidence of Infection from Permanent Pacemaker Implantation

Yun Lin | Zhi Zhong Li | ... | Jie Du
  • Special Issue
  • - Volume 2013
  • - Article ID 329183
  • - Research Article

Acute Hyperglycemia Abolishes Ischemic Preconditioning by Inhibiting Akt Phosphorylation: Normalizing Blood Glucose before Ischemia Restores Ischemic Preconditioning

Zequan Yang | Yikui Tian | ... | Brent A. French
  • Special Issue
  • - Volume 2013
  • - Article ID 912310
  • - Research Article

N-n-Butyl Haloperidol Iodide Ameliorates Cardiomyocytes Hypoxia/Reoxygenation Injury by Extracellular Calcium-Dependent and -Independent Mechanisms

Yanmei Zhang | Gaoyong Chen | ... | Ganggang Shi
  • Special Issue
  • - Volume 2013
  • - Article ID 529173
  • - Research Article

Protective Effects of Low-Frequency Magnetic Fields on Cardiomyocytes from Ischemia Reperfusion Injury via ROS and NO/ONOO

Sai Ma | Zhengxun Zhang | ... | Feng Cao
  • Special Issue
  • - Volume 2013
  • - Article ID 126083
  • - Research Article

Transient Acidosis during Early Reperfusion Attenuates Myocardium Ischemia Reperfusion Injury via PI3k-Akt-eNOS Signaling Pathway

Xin Qiao | Jinjin Xu | ... | Huimin Liu
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate48%
Submission to final decision56 days
Acceptance to publication37 days
CiteScore7.900
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